{"doi":"10.1111/liv.15619","title":"Novel treatment of acute and acute‐on‐chronic liver failure: Interleukin‐22","abstract":"Acute liver failure (ALF) is a life-threatening medical condition, characterized by rapidly progressive hepatic dysfunction, coagulopathy and hepatic encephalopathy in patients without chronic liver disease, while acute-on-chronic liver failure (ACLF) occurs in patients with existing chronic liver disease. ALF and ACLF are often associated with multiple organ failure and a high short-term mortality. In this review, we briefly discuss the causes and pathogenesis of ALF and ACLF, the current options available for the treatment of both deadly maladies and interleukin-22 (IL-22), a novel promising drug that may have great therapeutic potential for ALF and ACLF treatment. IL-22 is a cytokine produced by immune cells but mainly targets epithelial cells including hepatocytes. IL-22 has been shown to protect against organ damage and reduce bacterial infection in many preclinical models and several clinical trials including alcohol-associated hepatitis. The potential application of IL-22 for the treatment of ALF and ACLF is also elaborated.","journal":"Liver International","year":2023,"id":327654,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9497,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1048350,"name":"Amy Hicks","orcid":"0000-0002-7953-0797","position":1,"is_corresponding":false},{"id":1048351,"name":"Chai-Zhen Hoo","orcid":"0000-0003-0104-9247","position":2,"is_corresponding":false},{"id":1048352,"name":"Yong Seong Kwon","orcid":"0000-0002-5751-8578","position":3,"is_corresponding":false},{"id":644715,"name":"Ye Eun Cho","orcid":"0000-0002-9143-4300","position":4,"is_corresponding":false},{"id":1048353,"name":"Joanna Moore","orcid":"0000-0002-9559-3552","position":5,"is_corresponding":false},{"id":226858,"name":"Bin Gao","orcid":"0000-0002-0505-2972","position":6,"is_corresponding":false},{"id":251606,"name":"Seonghwan Hwang","orcid":"0000-0002-9728-3603","position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":null,"created_at":"2026-07-19T01:08:47.581262Z","pmid":"37208937","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}