{"doi":"10.1111/liv.14976","title":"The risk of hepatitis C virus recurrence in hepatitis C virus‐infected patients treated with direct‐acting antivirals after achieving a sustained virological response: A comprehensive analysis","abstract":"BACKGROUND & AIMS: The risk for hepatitis C virus (HCV) recurrence persists after HCV eradication with direct-acting antivirals (DAAs), particularly in patients with ongoing high-risk behaviours. Our aim was to assess the risk of HCV recurrence (late relapse and/or reinfection) post-sustained virological response (SVR). METHODS: We searched the literature for studies reporting HCV recurrence rates post-SVR in PubMed, Web of Science and the Cochrane Library. Identified publications were divided into groups based on patient risk for HCV reinfection: low-risk HCV mono-infection, high-risk HCV mono-infection and a human immunodeficiency virus (HIV)/HCV coinfection. The HCV recurrence rate for each study was calculated by using events divided by the person-years of follow-up (PYFU). HCV recurrence was defined as confirmed, detectable HCV RNA post-SVR. RESULTS: In the 16 studies of low-risk patients, the pooled recurrence rate was 0.89/1000 PYFU (95% confidence interval [CI], 0.16-2.03). For the 19 studies of high-risk patients, the pooled recurrence rate was 29.37/1000 PYFU (95% CI, 15.54-46.91). For the eight studies of HIV/HCV-coinfected patients, the pooled recurrence rate was 23.25/1000 PYFU (95% CI, 4.24-53.39). The higher pooled estimates of recurrence in the high-risk and HIV/HCV-coinfected populations were predominantly driven by an increase in reinfection rather than late relapse. CONCLUSIONS: The HCV recurrence risk after achieving SVR with all-oral DAAs therapy is low, and the risk of HCV recurrence in high-risk and HIV/HCV-coinfected populations was driven by an increase in reinfection rather than late relapse.","journal":"Liver International","year":2021,"id":194793,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9669,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":764813,"name":"Yan Wang","orcid":"0000-0002-1137-9971","position":1,"is_corresponding":false},{"id":764814,"name":"Ming Yue","orcid":"0000-0002-7677-0832","position":2,"is_corresponding":false},{"id":765305,"name":"Zhijun Ge","orcid":null,"position":3,"is_corresponding":false},{"id":764815,"name":"Xueshan Xia","orcid":"0000-0003-1120-8870","position":4,"is_corresponding":false},{"id":371327,"name":"Andre J. Jeyarajan","orcid":"0000-0002-6308-0859","position":5,"is_corresponding":false},{"id":678264,"name":"Jacinta A. Holmes","orcid":"0000-0002-7819-4904","position":6,"is_corresponding":false},{"id":738692,"name":"Rongbin Yu","orcid":"0000-0002-2255-3525","position":7,"is_corresponding":false},{"id":764816,"name":"Chuanwu Zhu","orcid":"0000-0002-9113-2046","position":8,"is_corresponding":false},{"id":253572,"name":"Sheng Yang","orcid":"0000-0003-3657-8771","position":9,"is_corresponding":false},{"id":299417,"name":"Wenyu Lin","orcid":"0000-0001-9913-9683","position":10,"is_corresponding":false},{"id":270866,"name":"Raymond T. Chung","orcid":"0000-0001-7587-718X","position":11,"is_corresponding":false},{"id":764812,"name":"Peng Huang","orcid":"0000-0002-0146-921X","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-18T23:49:59.476757Z","pmid":"34051040","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}