{"doi":"10.1111/liv.14514","title":"Objectively measured sedentary time, physical activity and liver enzyme elevations in US Hispanics/Latinos","abstract":"BACKGROUND & AIMS: Sedentariness and physical inactiveness are associated with deleterious health outcomes, but their associations with liver enzyme elevations remain uncertain. METHODS: In 10 385 US Hispanics/Latinos from the Hispanic Community Health Study/Study of Latinos, we examined associations of sedentary time and moderate-to-vigorous physical activity (MVPA) measured by accelerometers with liver enzyme elevations. Elevated alanine aminotransferase (ALT), aspartate aminotransferase and γ-glutamyltransferase (GGT) were defined as the highest gender-specific deciles. Prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated using weighted Poisson regressions. RESULTS: After adjusting for demographical/socioeconomic factors and MVPA, increasing quartiles of sedentary time were associated with a higher prevalence of elevated ALT (PRs [95% CI] = 1.0, 1.17 [0.92-1.47], 1.21 [0.96, 1.53] and 1.51 [1.13-2.02]; P-trend = .007) and elevated GGT (PRs [95% CI] = 1.0, 1.06 [0.82-1.36], 1.35 [1.06-1.73] and 1.66 [1.27-2.16]; P-trend = .0001). These associations were attenuated but remained significant after further adjustment for cardiometabolic traits including body-mass index, waist-hip-ratio, lipids and homeostatic model assessment of insulin resistance. In contrast, increasing quartiles of MVPA were associated with a lower prevalence of elevated ALT (PRs [95% CI] =1.0, 0.97 [0.77-1.23], 0.84 [0.66-1.06] and 0.72 [0.54-0.96]; P-trend = .01) after adjusting for demographical/socioeconomic factors and sedentary time, but this association became non-significant after further adjustment for cardiometabolic traits. Notably, the association of sedentary time with GGT elevation was significant both in individuals meeting the US Physical Activity Guidelines for Americans (MVPA ≥150 minutes/week) and in those who did not (both P-trend ≤ .003). CONCLUSIONS: Our findings suggest that objectively measured sedentary time is independently associated with elevated ALT and GGT in US Hispanics/Latinos.","journal":"Liver International","year":2020,"id":86882,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9496,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":368851,"name":"Simin Hua","orcid":"0000-0002-6282-8116","position":1,"is_corresponding":false},{"id":442318,"name":"Guo‐Chong Chen","orcid":"0000-0003-1853-6244","position":2,"is_corresponding":false},{"id":338099,"name":"Garrett Strizich","orcid":null,"position":3,"is_corresponding":false},{"id":425717,"name":"Mark H. Kuniholm","orcid":"0000-0002-0173-9806","position":4,"is_corresponding":false},{"id":249683,"name":"Zhilei Shan","orcid":"0000-0002-6723-3381","position":5,"is_corresponding":false},{"id":336206,"name":"Gregory A. Talavera","orcid":"0000-0001-5360-1107","position":6,"is_corresponding":false},{"id":270728,"name":"Sheila F. Castañeda","orcid":"0000-0002-1975-0544","position":7,"is_corresponding":false},{"id":336203,"name":"Marc D. Gellman","orcid":"0000-0003-4989-8627","position":8,"is_corresponding":false},{"id":336207,"name":"Jianwen Cai","orcid":"0000-0002-4945-6733","position":9,"is_corresponding":false},{"id":326124,"name":"Scott J. Cotler","orcid":"0000-0003-2564-7786","position":10,"is_corresponding":false},{"id":269896,"name":"Xuehong Zhang","orcid":"0000-0002-8260-8508","position":11,"is_corresponding":false},{"id":55333,"name":"Frank B. Hu","orcid":"0000-0002-8233-6274","position":12,"is_corresponding":false},{"id":21964,"name":"Robert C. Kaplan","orcid":"0000-0003-1571-4615","position":13,"is_corresponding":false},{"id":91398,"name":"Carmen R. Isasi","orcid":"0000-0003-2700-9593","position":14,"is_corresponding":false},{"id":90132,"name":"Qibin Qi","orcid":"0000-0002-2687-1758","position":15,"is_corresponding":false},{"id":333698,"name":"­Jun Li­","orcid":"0000-0002-7236-8088","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-18T21:59:03.706190Z","pmid":"32410310","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}