{"doi":"10.1111/jvim.14708","title":"Effect of Intravenous or Perivascular Injection of Synthetic Adrenocorticotropic Hormone on Stimulation Test Results in Dogs","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>Background</jats:title>\n                    <jats:p>Standard protocols for adrenocorticotropic hormone (ACTH) stimulation testing (ACTHst) often involve intravenous (IV) injection of corticotropin. ACTH might be unintentionally injected into the perivascular (PV) space.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective</jats:title>\n                    <jats:p>To compare stimulation test results after IV and PV injections of ACTH.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals</jats:title>\n                    <jats:p>Twenty privately owned dogs were studied: 10 healthy and 10 with trilostane-treated naturally occurring hyperadrenocorticism (HAC).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>Prospective study. Each of 20 dogs underwent 2 ACTHst not &amp;lt;4 nor more than 14 days apart. Five healthy and 5 HAC dogs had an IV ACTHst first and PV second; 5 healthy and 5 HAC dogs had a PV ACTHst first and IV second. Blood samples for measurement of serum cortisol concentration were collected before and 1 hour after ACTH administration.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>No significant difference in results was demonstrated when comparing serum cortisol concentrations after IV and PV ACTH administration in all 20 dogs (median μg/dL; interval μg/dL: 8.2; 1.4–17.4 versus 7.8; 0.9–16.9; P = .23). No significant difference in results was demonstrated when comparing serum cortisol concentrations after IV and PV ACTH administration in the 10 healthy dogs (median μg/dL; interval μg/dL: 10.9; 7.3–17.4 versus 10.6; 7.1–16.9; P = .54) or in the 10 HAC dogs (median μg/dL; interval μg/dL: 6.3; 1.4–8.6 versus 5.2; 0.9–8.7; P = .061).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance</jats:title>\n                    <jats:p>Perivascular administration of ACTH does not significantly alter stimulation test results in healthy dogs or in dogs with HAC undergoing therapy with trilostane.</jats:p>\n                  </jats:sec>","journal":"Journal of Veterinary Internal Medicine","year":2017,"id":16491,"datarank":0.3886717017016663,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.14725601483655124,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.14725601483655124,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":121529,"name":"P.H. Kass","orcid":null,"position":1,"is_corresponding":false},{"id":121530,"name":"T.A. Cohen","orcid":null,"position":2,"is_corresponding":false},{"id":121531,"name":"E.C. Feldman","orcid":null,"position":3,"is_corresponding":false},{"id":121528,"name":"C.M. Johnson","orcid":"0000-0001-9954-6238","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28407319","pmcid":null,"openalex_id":"https://openalex.org/W2607228433","authors":[],"funders":[],"total_grants":0,"fwci":0.335,"citation_percentile":0.58240863,"influential_citations":1,"citation_trend":[{"year":2018,"count":1},{"year":2022,"count":1},{"year":2025,"count":2}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jvim.14708","host_type":"journal"},{"url":"https://doi.org/10.1111/jvim.14708","host_type":"GOLD"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jvim.14708","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjvim.14708","host_type":"publisher"},{"url":"https://academic.oup.com/jvim/article-pdf/31/3/730/66668472/jvim14708.pdf","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28407319","host_type":"repository"},{"url":"https://escholarship.org/uc/item/28f3h86m","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5435047","host_type":"repository"}],"fields_of_study":["Veterinary Medicine and Surgery","Adrenal Hormones and Disorders","Veterinary Orthopedics and Neurology","Medicine"],"mesh_terms":["Adrenocortical Hyperfunction","Adrenocorticotropic Hormone","Animals","Dog Diseases","Dogs","Female","Hydrocortisone","Injections, Intravenous","Injections, Subcutaneous","Male","Case-Control Studies"],"keywords":["Medicine","Adrenocorticotropic hormone","Stimulation","ACTH stimulation test","Internal medicine","Endocrinology","Hormone"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-02T09:29:47.560992Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}