{"doi":"10.1111/jvh.13874","title":"Prevalence and determinants of hepatitis delta virus infection among <scp>HIV</scp>/hepatitis <scp>B‐coinfected</scp> adults in care in the United States","abstract":"Hepatitis delta virus (HDV) infection increases the risk of liver complications compared to hepatitis B virus (HBV) alone, particularly among persons with human immunodeficiency virus (HIV). However, no studies have evaluated the prevalence or determinants of HDV infection among people with HIV/HBV in the US. We performed a cross-sectional study among adults with HIV/HBV coinfection receiving care at eight sites within the Center for AIDS Research Network of Integrated Clinical Systems (CNICS) between 1996 and 2019. Among patients with available serum/plasma specimens, we selected the first specimen on or after their initial HBV qualifying test. All samples were tested for HDV IgG antibody and HDV RNA. Multivariable log-binomial generalized linear models were used to estimate prevalence ratios (PRs) with 95% CIs of HDV IgG antibody-positivity associated with determinants of interest (age, injection drug use [IDU], high-risk sexual behaviour). Among 597 adults with HIV/HBV coinfection in CNICS and available serum/plasma samples (median age, 43 years; 89.9% male; 52.8% Black; 42.4% White), 24/597 (4.0%; 95% CI, 2.4%-5.6%) were HDV IgG antibody-positive, and 10/596 (1.7%; 95% CI, 0.6%-2.7%) had detectable HDV RNA. In multivariable analysis, IDU was associated with exposure to HDV infection (adjusted PR = 2.50; 95% CI, 1.09-5.74). In conclusion, among a sample of adults with HIV/HBV coinfection in care in the US, 4.0% were HDV IgG antibody-positive, among whom 41.7% had detectable HDV RNA. History of IDU was associated with exposure to HDV infection. These findings emphasize the importance of HDV testing among persons with HIV/HBV coinfection, especially those with a history of IDU.","journal":"Journal of Viral Hepatitis","year":2023,"id":364258,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9637,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1119473,"name":"Michael J. Kallan","orcid":null,"position":1,"is_corresponding":false},{"id":1032188,"name":"Sophia Sukkestad","orcid":"0000-0002-0877-0400","position":2,"is_corresponding":false},{"id":409720,"name":"Maja Kodani","orcid":"0000-0002-2249-5994","position":3,"is_corresponding":false},{"id":340159,"name":"Mari M. Kitahata","orcid":"0000-0002-5410-7175","position":4,"is_corresponding":false},{"id":428437,"name":"Edward R. Cachay","orcid":"0000-0002-2452-7558","position":5,"is_corresponding":false},{"id":442329,"name":"Debika Bhattacharya","orcid":"0000-0002-2136-7763","position":6,"is_corresponding":false},{"id":385134,"name":"Sonya L. Heath","orcid":"0000-0002-3826-0954","position":7,"is_corresponding":false},{"id":340146,"name":"Sonia Napravnik","orcid":"0000-0002-9032-3713","position":8,"is_corresponding":false},{"id":240242,"name":"Richard D. Moore","orcid":"0000-0001-8250-5069","position":9,"is_corresponding":false},{"id":691108,"name":"George A. Yendewa","orcid":"0000-0002-8474-1812","position":10,"is_corresponding":false},{"id":305156,"name":"Kenneth H. Mayer","orcid":"0000-0001-7460-733X","position":11,"is_corresponding":false},{"id":40940,"name":"K. Rajender Reddy","orcid":"0000-0002-4898-7778","position":12,"is_corresponding":false},{"id":427620,"name":"Tonya Hayden","orcid":null,"position":13,"is_corresponding":false},{"id":426919,"name":"Saleem Kamili","orcid":"0000-0002-7984-9044","position":14,"is_corresponding":false},{"id":239684,"name":"Jeffrey N. Martin","orcid":"0000-0002-9773-3256","position":15,"is_corresponding":false},{"id":496105,"name":"H. Nina Kim","orcid":"0000-0001-6710-9666","position":16,"is_corresponding":false},{"id":463615,"name":"Vincent Lo Re","orcid":"0000-0001-7955-0600","position":17,"is_corresponding":false},{"id":1119052,"name":"Nicole Ferrante","orcid":"0000-0001-8794-9304","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T01:14:36.728255Z","pmid":"37488783","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}