{"doi":"10.1111/jsr.70204","title":"Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus","abstract":"ABSTRACT\n \n The prevalence of obstructive sleep apnea (\n OSA\n ) increases during pregnancy and is associated with gestational diabetes mellitus (\n GDM\n ), although its clinical impact on birth outcomes remains unclear. We aimed to assess the effect of several\n OSA\n criteria and intermittent hypoxia in the third trimester on perinatal outcomes in women with\n GDM\n . In this prospective study, polysomnography was performed on 89 women with\n GDM\n . Insulin resistance indices (\n HOMA\n ‐\n IR\n /\n QUICKI\n ) were calculated, and biomarkers (insulin‐like growth factor‐1 (\n IGF\n ‐1), resistin, soluble endoglobulin, galectin‐3, and free fatty acids) were analysed from women and some cord blood samples using enzyme‐linked immunosorbent assay. Whereas\n OSA\n did not significantly affect overall perinatal outcomes, specific\n OSA\n features—including\n REM\n ‐\n OSA\n , supine‐position\n OSA\n , and an oxygen desaturation index (\n ODI\n ) ≥ 1 h\n −1\n —were linked to adverse effects on neonatal birthweight and length. Moreover, apnea duration was an independent predictor of birthweight, while insulin resistance was more impaired in women with\n OSA\n and showed an inverse relationship with sleep and\n REM\n time, respectively.\n IGF\n ‐1 was elevated and demonstrated a significant predictive value for\n OSA\n , as indicated by the\n AUC\n –\n ROC\n curve. In summary, although\n OSA\n did not adversely affect overall perinatal outcomes in women with\n GDM\n , specific\n OSA\n characteristics were associated with adverse neonatal growth metrics. Insulin resistance was higher in women with\n OSA\n , and\n IGF\n ‐1 may serve as a potential biomarker for\n OSA\n in this population. Further prospective studies with attention to\n REM\n ‐stage, supine‐position\n OSA\n , apnea duration, and hypoxic burden are needed to elucidate the complex interactions between\n OSA\n ,\n GDM\n , and fetal outcomes.\n ","journal":"Journal of Sleep Research","year":2026,"id":615036,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1585041,"name":"Oleksandr Serednytskyy","orcid":null,"position":1,"is_corresponding":false},{"id":1585042,"name":"Ainhoa Álvarez Ruiz De Larrinaga","orcid":null,"position":2,"is_corresponding":false},{"id":1585043,"name":"Laura Cànaves‐Gómez","orcid":null,"position":3,"is_corresponding":false},{"id":1585044,"name":"Andrés Sánchez Barón","orcid":null,"position":4,"is_corresponding":false},{"id":1585045,"name":"Mercedes Codina Marcet","orcid":null,"position":5,"is_corresponding":false},{"id":1585046,"name":"Mónica De La Peña Bravo","orcid":null,"position":6,"is_corresponding":false},{"id":1585047,"name":"Amanda Iglesias Coma","orcid":null,"position":7,"is_corresponding":false},{"id":1585048,"name":"Daniel Morell‐Garcia","orcid":null,"position":8,"is_corresponding":false},{"id":1585049,"name":"José Antonio Peña Zarza","orcid":null,"position":9,"is_corresponding":false},{"id":1585050,"name":"María Paloma Giménez Carrero","orcid":null,"position":10,"is_corresponding":false},{"id":1585051,"name":"María Concepción Piñas Cebrian","orcid":null,"position":11,"is_corresponding":false},{"id":1585052,"name":"Susana García Fernández","orcid":null,"position":12,"is_corresponding":false},{"id":407278,"name":"Francisco García‐Río","orcid":"0000-0002-7227-2238","position":13,"is_corresponding":false},{"id":1585053,"name":"Alberto Alonso‐Fernández","orcid":null,"position":14,"is_corresponding":false},{"id":1585040,"name":"María Cerdà Moncadas","orcid":"0000-0002-7029-5276","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Influence of Obstructive Sleep Apnea on Maternal and Perinatal Outcomes in Patients With Gestational Diabetes Mellitus","abstract":"ABSTRACT\n \n The prevalence of obstructive sleep apnea (\n OSA\n ) increases during pregnancy and is associated with gestational diabetes mellitus (\n GDM\n ), although its clinical impact on birth outcomes remains unclear. We aimed to assess the effect of several\n OSA\n criteria and intermittent hypoxia in the third trimester on perinatal outcomes in women with\n GDM\n . In this prospective study, polysomnography was performed on 89 women with\n GDM\n . Insulin resistance indices (\n HOMA\n ‐\n IR\n /\n QUICKI\n ) were calculated, and biomarkers (insulin‐like growth factor‐1 (\n IGF\n ‐1), resistin, soluble endoglobulin, galectin‐3, and free fatty acids) were analysed from women and some cord blood samples using enzyme‐linked immunosorbent assay. Whereas\n OSA\n did not significantly affect overall perinatal outcomes, specific\n OSA\n features—including\n REM\n ‐\n OSA\n , supine‐position\n OSA\n , and an oxygen desaturation index (\n ODI\n ) ≥ 1 h\n −1\n —were linked to adverse effects on neonatal birthweight and length. Moreover, apnea duration was an independent predictor of birthweight, while insulin resistance was more impaired in women with\n OSA\n and showed an inverse relationship with sleep and\n REM\n time, respectively.\n IGF\n ‐1 was elevated and demonstrated a significant predictive value for\n OSA\n , as indicated by the\n AUC\n –\n ROC\n curve. In summary, although\n OSA\n did not adversely affect overall perinatal outcomes in women with\n GDM\n , specific\n OSA\n characteristics were associated with adverse neonatal growth metrics. Insulin resistance was higher in women with\n OSA\n , and\n IGF\n ‐1 may serve as a potential biomarker for\n OSA\n in this population. Further prospective studies with attention to\n REM\n ‐stage, supine‐position\n OSA\n , apnea duration, and hypoxic burden are needed to elucidate the complex interactions between\n OSA\n ,\n GDM\n , and fetal outcomes.\n ","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40965004","pmcid":"PMC13193430","openalex_id":"https://openalex.org/W4414333169","authors":[],"funders":[{"funder_name":"Ministerio de Ciencia, Innovación y Universidades","grant_id":"PI19/00875","title":null},{"funder_name":"Ministerio de Economía y Competitividad","grant_id":"PI11/00495","title":null},{"funder_name":"Sociedad Española de Neumología y Cirugía Torácica","grant_id":"2020‐820","title":null},{"funder_name":"Sociedad Española de Neumología y Cirugía Torácica","grant_id":"2020-820","title":null},{"funder_name":"Ramon llull program","grant_id":"","title":null},{"funder_name":"Ramon llull program","grant_id":"","title":null}],"total_grants":6,"fwci":1.9418,"citation_percentile":0.87044361,"influential_citations":0,"citation_trend":[{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jsr.70204","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jsr.70204","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jsr.70204","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jsr.70204","host_type":"publisher"},{"url":"https://doi.org/10.1111/jsr.70204","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40965004","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13193430/","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC13193430","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC13193430?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Obstructive Sleep Apnea Research","Gestational Diabetes Research and Management","Neuroscience of respiration and sleep","Humans","Female","Sleep Apnea, Obstructive","Pregnancy","Diabetes, Gestational","Adult","Prospective Studies","Polysomnography","Insulin Resistance","Pregnancy Outcome","Biomarkers","Infant, Newborn","Insulin-Like Growth Factor I","Birth Weight","Pregnancy Trimester, Third"],"mesh_terms":["Adult","Birth Weight","Female","Humans","Infant, Newborn","Insulin Resistance","Insulin-Like Growth Factor I","Pregnancy","Pregnancy Outcome","Pregnancy Trimester, Third","Prospective Studies","Biomarkers","Diabetes, Gestational","Polysomnography","Sleep Apnea, Obstructive"],"keywords":["Obstructive sleep apnea","Insulin resistance","Gestational diabetes","Polysomnography","Prospective cohort study","Pregnancy","Sleep apnea","Diabetes mellitus","Apnea","Gestational Diabetes Mellitus","Apnea–hypopnea Index","Fetal Outcomes","Maternal–fetal Health"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T18:37:00.142624Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}