{"doi":"10.1111/jsr.70180","title":"Cerebral and Peripheral Hemodynamics Across Wakefulness and <scp>NREM</scp> Sleep","abstract":"Wake/sleep-related changes in cerebral hemodynamic oscillations are well established, but similar changes in peripheral hemodynamics remain largely understudied. Moreover, how the relationship between cerebral and peripheral hemodynamics varies across sleep-wake states is not well understood, despite evidence that these oscillations in the low-frequency range are strongly coupled during wakefulness. In this study, we investigated the temporal and spectral characteristics of cerebral and peripheral hemodynamics, as well as their low-frequency coupling, across sleep and wake states. To this end, we simultaneously measured cerebral hemodynamics using functional magnetic resonance imaging (fMRI) of the brain and peripheral hemodynamics using near-infrared spectroscopy (NIRS) of the fingertips in 10 healthy participants (6 females; age 19-24 years, mean ± SD: 20.90 ± 1.59 years) during wakefulness and non-rapid eye movement (NREM) sleep. Our results show that during sleep, cerebral hemodynamics differ markedly from peripheral hemodynamics in both oscillation amplitude and spectral power. Furthermore, low-frequency coupling between cerebral and peripheral hemodynamics becomes desynchronized during NREM3 sleep. These findings support the notion that NREM3 sleep plays a key role in the optimal restoration of cerebral vasomotion.","journal":"Journal of Sleep Research","year":2025,"id":572866,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9494,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":813496,"name":"Brianna Kish","orcid":"0000-0001-5906-1295","position":1,"is_corresponding":false},{"id":1479411,"name":"Hideyuki Oshima","orcid":"0000-0002-6557-1344","position":2,"is_corresponding":false},{"id":297388,"name":"Qiuting Wen","orcid":"0000-0002-7885-4036","position":3,"is_corresponding":false},{"id":429987,"name":"Yunjie Tong","orcid":"0000-0001-6052-8913","position":4,"is_corresponding":false},{"id":376363,"name":"A. J. Schwichtenberg","orcid":"0000-0002-8920-6798","position":5,"is_corresponding":false},{"id":813495,"name":"Vidhya Vijayakrishnan Nair","orcid":"0000-0002-9454-8645","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T02:57:27.876396Z","pmid":"40832793","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}