{"doi":"10.1111/jpc.12122","title":"<scp>C</scp>‐reactive protein versus erythrocyte sedimentation rate, white blood cell count and alkaline phosphatase in diagnosing bacteraemia in bone and joint infections","abstract":"<jats:sec><jats:title>Aim</jats:title><jats:p>Bacteraemia is common in childhood acute bone and joint infections and demands urgent treatment. Blood <jats:styled-content style=\"fixed-case\">C</jats:styled-content>‐reactive protein (<jats:styled-content style=\"fixed-case\">CRP</jats:styled-content>), erythrocyte sedimentation rate and white blood cell count (<jats:styled-content style=\"fixed-case\">WBC</jats:styled-content>) are well known and established markers in these infections. Instead, no information is available on serum alkaline phosphatase whose concentration is known to increase in septic conditions.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In our large prospective treatment trial comprising of 265 children with acute culture‐positive bone or joint infection, all these laboratory indices were monitored on admission to hospital. The predictive value to detect bacteraemia was assessed for each of these four indices.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In all, 59% of the patients showed bacteraemia. <jats:styled-content style=\"fixed-case\">CRP</jats:styled-content> was significantly (<jats:italic>P</jats:italic> &lt; 0.05) higher among bacteraemic patients, whereas erythrocyte sedimentation rate, white blood cell count and alkaline phosphatase were not. The area under receiver operator characteristic curve for <jats:styled-content style=\"fixed-case\">CRP</jats:styled-content> was 0.588 (<jats:styled-content style=\"fixed-case\">CI</jats:styled-content><jats:sub>95%</jats:sub> 0.524–0.649) and the significance level <jats:italic>P</jats:italic> (Area = 0.5) was &lt;0.05.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>None of the markers could reliably diagnose bacteraemia. <jats:styled-content style=\"fixed-case\">CRP</jats:styled-content> alone was significantly higher among bacteraemic patients.</jats:p></jats:sec>","journal":"Journal of Paediatrics and Child Health","year":2013,"id":596641,"datarank":0.5709993734655481,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"self_citation_contribution":0.5709993734655481,"citation_network_contribution":0.0,"self_endowment_contribution":0.5709993734655481,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1528111,"name":"Markku JT Kallio","orcid":null,"position":1,"is_corresponding":false},{"id":1528112,"name":"Pentti E Kallio","orcid":null,"position":2,"is_corresponding":false},{"id":1528113,"name":"Heikki Peltola","orcid":null,"position":3,"is_corresponding":false},{"id":1528110,"name":"Markus Pääkkönen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"<scp>C</scp>‐reactive protein versus erythrocyte sedimentation rate, white blood cell count and alkaline phosphatase in diagnosing bacteraemia in bone and joint infections","abstract":"<jats:sec><jats:title>Aim</jats:title><jats:p>Bacteraemia is common in childhood acute bone and joint infections and demands urgent treatment. Blood <jats:styled-content style=\"fixed-case\">C</jats:styled-content>‐reactive protein (<jats:styled-content style=\"fixed-case\">CRP</jats:styled-content>), erythrocyte sedimentation rate and white blood cell count (<jats:styled-content style=\"fixed-case\">WBC</jats:styled-content>) are well known and established markers in these infections. Instead, no information is available on serum alkaline phosphatase whose concentration is known to increase in septic conditions.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In our large prospective treatment trial comprising of 265 children with acute culture‐positive bone or joint infection, all these laboratory indices were monitored on admission to hospital. The predictive value to detect bacteraemia was assessed for each of these four indices.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In all, 59% of the patients showed bacteraemia. <jats:styled-content style=\"fixed-case\">CRP</jats:styled-content> was significantly (<jats:italic>P</jats:italic> &lt; 0.05) higher among bacteraemic patients, whereas erythrocyte sedimentation rate, white blood cell count and alkaline phosphatase were not. The area under receiver operator characteristic curve for <jats:styled-content style=\"fixed-case\">CRP</jats:styled-content> was 0.588 (<jats:styled-content style=\"fixed-case\">CI</jats:styled-content><jats:sub>95%</jats:sub> 0.524–0.649) and the significance level <jats:italic>P</jats:italic> (Area = 0.5) was &lt;0.05.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>None of the markers could reliably diagnose bacteraemia. <jats:styled-content style=\"fixed-case\">CRP</jats:styled-content> alone was significantly higher among bacteraemic patients.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23438321","pmcid":null,"openalex_id":"https://openalex.org/W1932065333","authors":[],"funders":[],"total_grants":0,"fwci":3.067,"citation_percentile":0.90553679,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":3},{"year":2015,"count":4},{"year":2016,"count":3},{"year":2017,"count":1},{"year":2018,"count":7},{"year":2019,"count":3},{"year":2020,"count":3},{"year":2021,"count":3},{"year":2022,"count":4},{"year":2023,"count":5},{"year":2024,"count":1},{"year":2025,"count":4},{"year":2026,"count":2}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjpc.12122","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jpc.12122","host_type":"publisher"},{"url":"https://doi.org/10.1111/jpc.12122","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23438321","host_type":"repository"}],"fields_of_study":["Orthopedic Infections and Treatments","Hematological disorders and diagnostics","Neonatal and Maternal Infections","Adolescent","Alkaline Phosphatase","Area Under Curve","Arthritis, Infectious","Bacteremia","Biomarkers","Blood Sedimentation","C-Reactive Protein","Child","Child, Preschool","Female","Humans","Infant","Leukocyte Count","Male","Osteomyelitis","Predictive Value of Tests","Prospective Studies"],"mesh_terms":["Adolescent","Alkaline Phosphatase","Arthritis, Infectious","Blood Sedimentation","C-Reactive Protein","Child","Child, Preschool","Female","Humans","Infant","Leukocyte Count","Male","Osteomyelitis","Predictive Value of Tests","Prospective Studies","Biomarkers","Bacteremia","Area Under Curve"],"keywords":["Erythrocyte sedimentation rate","Medicine","White blood cell","Alkaline phosphatase","C-reactive protein","Internal medicine","Gastroenterology","Bacteremia","Prospective cohort study","Red blood cell","Immunology","Microbiology","Antibiotics","Inflammation","Enzyme","Biology","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T10:51:12.171700Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}