{"doi":"10.1111/jns.12531","title":"Neutrophil‐lymphocyte ratio in <scp>Guillain‐Barré</scp> syndrome: A prognostic biomarker of severe <scp>disease</scp> and mechanical ventilation in Bangladesh","abstract":"In addition to cellular and humoral immunity, inflammatory markers play an important role in the pathogenesis of Guillain-Barré syndrome (GBS) and are used to predict prognosis in many autoimmune diseases. The aim of this study was to identify whether the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio, and monocyte-lymphocyte ratio in the early stages of GBS have prognostic value for severe disease, mechanical ventilation (MV) and poor long-term outcome. A prospective cohort study of 140 adult patients with GBS and 140 healthy controls (HC) was performed in Bangladesh during 2019-2022. Clinicodemographic characteristics of the patients were recorded, and hematological parameters were measured using an automated hematology analyzer. Median patient age was 35 (44-23) years; 71% were male; 88% were severely affected (GBS Disability Score> 3); 32% required MV. Patients had higher NLR than HC (P< .0001). Among patients, elevated NLR was associated with severe GBS and MV (P= .001 and <.0001, respectively) and moderately positively correlated with poor outcomes at 4 weeks (r = 0.423). Multiple logistic regression revealed NLR was an independent risk factor for severe GBS (OR = 5.2, 95% CI = 1.6-17.4) and MV (OR = 1.5 1.1-2.1). No significant association was observed between elevated NLR and the long-term outcome of GBS. Receiver operating characteristic curves revealed NLR cut-off values of ≥ 2.432 and ≥ 4.4423 predicted severe disease (sensitivity = 71%, specificity = 75%, AUC = 0.750, 95% CI = 0.651-0.849, P = .001) and MV (sensitivity = 65.9%, specificity = 81.7%, AUC = 0.804, 95% CI=0.724-0.884; P< .001). The NLR in the early stage of GBS may represent an independent prognostic factor of severe GBS and the requirement for MV.","journal":"Journal of the Peripheral Nervous System","year":2023,"id":339237,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9586,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1072821,"name":"Rasel Ahmed","orcid":"0000-0002-7756-0992","position":1,"is_corresponding":false},{"id":1072822,"name":"Jigishu Ahmed","orcid":"0000-0002-1857-5705","position":2,"is_corresponding":false},{"id":1073276,"name":"Sarah Khurshid","orcid":null,"position":3,"is_corresponding":false},{"id":1073277,"name":"Pritha Promita Biswas","orcid":null,"position":4,"is_corresponding":false},{"id":1073278,"name":"I. Upama","orcid":null,"position":5,"is_corresponding":false},{"id":820496,"name":"Yameen Hamid","orcid":"0000-0002-0948-7746","position":6,"is_corresponding":false},{"id":639574,"name":"Nowshin Papri","orcid":null,"position":7,"is_corresponding":false},{"id":530226,"name":"Zhahirul Islam","orcid":"0000-0003-0935-8079","position":8,"is_corresponding":false},{"id":791058,"name":"Israt Jahan","orcid":"0000-0001-9594-0705","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T01:10:45.048445Z","pmid":"36700342","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}