{"doi":"10.1111/jne.12473","title":"The regulation and role of carbohydrate response element‐binding protein in metabolic homeostasis and disease","abstract":"<jats:p>The transcription factor carbohydrate response element‐binding protein (Ch<jats:styled-content style=\"fixed-case\">REBP</jats:styled-content>) is a member of the basic helix‐loop‐helix leucine zipper transcription factor family. Under high‐glucose conditions, it has a role in regulating the expression of key genes involved in various pathways, including glycolysis, gluconeogenesis and lipogenesis. It does this by forming a tetrameric complex made up of two Ch<jats:styled-content style=\"fixed-case\">REBP</jats:styled-content>/Mlx heterodimers, which enables it to bind to the carbohydrate response element (Cho<jats:styled-content style=\"fixed-case\">RE</jats:styled-content>) in the promoter region of its target genes to regulate transcription. Because Ch<jats:styled-content style=\"fixed-case\">REBP</jats:styled-content> plays a key role in glucose signalling and metabolism, and aberrations in glucose homeostasis are often present in metabolic diseases, this transcription factor presents itself as an enticing target with respect to further understanding metabolic disease mechanisms and potentially uncovering new therapeutic targets.</jats:p>","journal":"Journal of Neuroendocrinology","year":2017,"id":20894,"datarank":0.8394532105249389,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.43324568035960737,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.43324568035960737,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":14,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":136558,"name":"M. 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