{"doi":"10.1111/jnc.70313","title":"Clinical Validation of Novel Immunoassays for Plasma Phosphorylated Tau 217, 212, 181, 231, and Brain‐Derived Tau Across the Biochemical Spectrum of Alzheimer's Disease","abstract":"Plasma biomarkers have emerged as promising less invasive alternatives for Alzheimer's disease (AD) detection. However, the diagnostic performance of phosphorylated tau (p-tau) isoforms remains incompletely validated. In a cohort of 160 patients from a memory clinic, plasma levels of p-tau217, p-tau212, p-tau181, p-tau231, and BD-tau were measured using Single Molecule Array (Simoa) in-house assays, alongside NFL and GFAP. Subjects were classified using the Erlangen Score into Controls (n = 53), neurochemically possible AD (n = 27), and probable AD (n = 80). Plasma concentrations of all p-tau isoforms were significantly elevated in both Possible AD and Probable AD groups compared to Controls (p < 0.001). Notably, p-tau217 exhibited the highest diagnostic accuracy (AUC = 0.954) and correlated with CSF classical biomarkers. A positive result for p-tau217 increases the probability of AD almost fivefold. Plasma p-tau217 reflects AD neurochemical changes and has high negative predictive value, supporting its use as a screening tool. However, moderate PPV suggests the need for confirmatory testing to ensure an accurate diagnosis.","journal":"Journal of Neurochemistry","year":2025,"id":535600,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9543,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":841866,"name":"Przemysław R. Kac","orcid":"0000-0001-5083-0924","position":1,"is_corresponding":false},{"id":1419219,"name":"Fernando C. Ortíz","orcid":"0000-0002-4776-4492","position":2,"is_corresponding":false},{"id":241105,"name":"Thomas K. Karikari","orcid":"0000-0003-1422-4358","position":3,"is_corresponding":false},{"id":1207332,"name":"Agnieszka Kulczyńska‐Przybik","orcid":"0000-0002-9889-3585","position":4,"is_corresponding":false},{"id":1207334,"name":"Barbara Mroczko","orcid":"0000-0002-4075-8479","position":5,"is_corresponding":false},{"id":843049,"name":"Michael Turton","orcid":null,"position":6,"is_corresponding":false},{"id":1274962,"name":"Peter Harrison","orcid":"0000-0001-7526-4834","position":7,"is_corresponding":false},{"id":1419732,"name":"Manuel Maler","orcid":null,"position":8,"is_corresponding":false},{"id":1419220,"name":"Timo Jan Oberstein","orcid":"0000-0002-4369-6875","position":9,"is_corresponding":false},{"id":613836,"name":"Johannes Kornhuber","orcid":"0000-0002-8096-3987","position":10,"is_corresponding":false},{"id":297183,"name":"Jörg Hanrieder","orcid":"0000-0001-6059-198X","position":11,"is_corresponding":false},{"id":27601,"name":"Henrik Zetterberg","orcid":"0000-0003-3930-4354","position":12,"is_corresponding":false},{"id":27600,"name":"Kaj Blennow","orcid":"0000-0002-1890-4193","position":13,"is_corresponding":false},{"id":846032,"name":"Piotr Lewczuk","orcid":"0000-0002-8101-6535","position":14,"is_corresponding":false},{"id":1037288,"name":"Maciej Dulewicz","orcid":"0000-0002-7149-017X","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:51:56.297114Z","pmid":"41321279","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}