{"doi":"10.1111/jnc.15313","title":"A ketogenic diet differentially affects neuron and astrocyte transcription","abstract":"Ketogenic diets (KDs) alter brain metabolism. Multiple mechanisms may account for their effects, and different brain regions may variably respond. Here, we considered how a KD affects brain neuron and astrocyte transcription. We placed male C57Bl6/N mice on either a 3-month KD or chow diet, generated enriched neuron and astrocyte fractions, and used RNA-Seq to assess transcription. Neurons from KD-treated mice generally showed transcriptional pathway activation while their astrocytes showed a mix of transcriptional pathway suppression and activation. The KD especially affected pathways implicated in mitochondrial and endoplasmic reticulum function, insulin signaling, and inflammation. An unbiased analysis of KD-associated expression changes strongly implicated transcriptional pathways altered in AD, which prompted us to explore in more detail the potential molecular relevance of a KD to AD. Our results indicate a KD differently affects neurons and astrocytes, and provide unbiased evidence that KD-induced brain effects are potentially relevant to neurodegenerative diseases such as AD.","journal":"Journal of Neurochemistry","year":2021,"id":169795,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9604,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":378208,"name":"Dong Pei","orcid":"0000-0002-8367-729X","position":1,"is_corresponding":false},{"id":583155,"name":"Heather Wilkins","orcid":"0000-0003-4563-4544","position":2,"is_corresponding":false},{"id":280800,"name":"Ian Weidling","orcid":"0009-0009-5277-7149","position":3,"is_corresponding":false},{"id":583156,"name":"Xiaowan Wang","orcid":"0000-0001-9152-8908","position":4,"is_corresponding":false},{"id":701053,"name":"Blaise W. Menta","orcid":"0000-0002-1001-2078","position":5,"is_corresponding":false},{"id":701054,"name":"Judit Perez Ortiz","orcid":"0000-0002-8953-4281","position":6,"is_corresponding":false},{"id":701055,"name":"Anuradha Kalani","orcid":"0000-0003-0856-7637","position":7,"is_corresponding":false},{"id":701056,"name":"Sharon Manley","orcid":"0000-0002-2411-9706","position":8,"is_corresponding":false},{"id":701552,"name":"Lesya Novikova","orcid":null,"position":9,"is_corresponding":false},{"id":341806,"name":"Devin C. Koestler","orcid":"0000-0002-0598-0146","position":10,"is_corresponding":false},{"id":107455,"name":"Russell H. Swerdlow","orcid":"0000-0003-2948-7230","position":11,"is_corresponding":false},{"id":701052,"name":"Scott J. Koppel","orcid":"0000-0001-9001-4454","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-18T23:46:15.560174Z","pmid":"33539571","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}