{"doi":"10.1111/jmp.12551","title":"Nef‐specific CD107a<sup>+</sup> CD4<sup>+</sup> T‐cell responses in a rhesus macaque (<i>Macaca mulatta</i>) showing partial simian immunodeficiency virus control following passive neutralizing antibody infusion","abstract":"<jats:title>Abstract</jats:title><jats:p>Acute‐phase neutralizing antibody (NAb) passive immunization in simian immunodeficiency virus (SIV)‐infected rhesus macaques (<jats:italic>Macaca mulatta</jats:italic>) can confer stringent viremia control with T‐cell augmentation. In one NAb‐infused SIV partial controller, we identify chronic‐phase Nef‐specific CD107a<jats:sup>+</jats:sup> CD4<jats:sup>+</jats:sup> T‐cell response maintenance, implicating that NAb infusion modulates long‐term T‐cell responses even within viremic control.</jats:p>","journal":"Journal of Medical Primatology","year":2022,"id":598468,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1533582,"name":"Yoshiaki Kanno","orcid":null,"position":1,"is_corresponding":false},{"id":1066513,"name":"Masako Nishizawa","orcid":"0000-0003-3536-9652","position":2,"is_corresponding":false},{"id":1533583,"name":"Takushi Nomura","orcid":null,"position":3,"is_corresponding":false},{"id":391275,"name":"Tetsuro Matano","orcid":"0000-0003-3096-6749","position":4,"is_corresponding":false},{"id":1066517,"name":"Hiroyuki Yamamoto","orcid":"0000-0002-0708-9373","position":5,"is_corresponding":false},{"id":1533581,"name":"Trang Thi Thu Hau","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Nef‐specific CD107a<sup>+</sup> CD4<sup>+</sup> T‐cell responses in a rhesus macaque (<i>Macaca mulatta</i>) showing partial simian immunodeficiency virus control following passive neutralizing antibody infusion","abstract":"<jats:title>Abstract</jats:title><jats:p>Acute‐phase neutralizing antibody (NAb) passive immunization in simian immunodeficiency virus (SIV)‐infected rhesus macaques (<jats:italic>Macaca mulatta</jats:italic>) can confer stringent viremia control with T‐cell augmentation. In one NAb‐infused SIV partial controller, we identify chronic‐phase Nef‐specific CD107a<jats:sup>+</jats:sup> CD4<jats:sup>+</jats:sup> T‐cell response maintenance, implicating that NAb infusion modulates long‐term T‐cell responses even within viremic control.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34750827","pmcid":null,"openalex_id":"https://openalex.org/W3213385236","authors":[],"funders":[{"funder_name":"Takeda Science Foundation","grant_id":"","title":null}],"total_grants":1,"fwci":0.0,"citation_percentile":0.13103936,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jmp.12551","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jmp.12551","host_type":"publisher"},{"url":"https://doi.org/10.1111/jmp.12551","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34750827","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","Immune Cell Function and Interaction","T-cell and B-cell Immunology","Animals","Antibodies, Neutralizing","CD4-Positive T-Lymphocytes","Macaca mulatta","Simian Acquired Immunodeficiency Syndrome","Simian Immunodeficiency Virus","T-Lymphocytes"],"mesh_terms":["Animals","Macaca mulatta","T-Lymphocytes","Simian Immunodeficiency Virus","CD4-Positive T-Lymphocytes","Simian Acquired Immunodeficiency Syndrome","Antibodies, Neutralizing","Simian immunodeficiency virus"],"keywords":["Simian immunodeficiency virus","Rhesus macaque","Viremia","Virology","Neutralizing antibody","Antibody","Biology","Immunology","Macaque","Immunodeficiency","Virus","Immune system","Passive immunization","SIV","Cd4+ T Cells","Cd107a"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T15:46:16.858596Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}