{"doi":"10.1111/jmp.12524","title":"Efficiency of whole‐exome sequencing in old world and new world primates using human capture reagents","abstract":"BACKGROUND: Whole-exome sequencing (WES) can expedite research on genetic variation in non-human primate (NHP) models of human diseases. However, NHP-specific reagents for exome capture are not available. This study reports the use of human-specific capture reagents in WES for olive baboons, marmosets, and vervet monkeys. METHODS: Exome capture was carried out using the SureSelect Human All Exon V6 panel from Agilent Technologies, followed by high-throughput sequencing. Capture of protein-coding genes and detection of single nucleotide variants were evaluated. RESULTS: Exome capture and sequencing results showed that more than 97% of old world and 93% of new world monkey protein coding genes were detected. Single nucleotide variants were detected across the genomes and missense variants were found in genes associated with human diseases. CONCLUSIONS: A cost-effective approach based on commercial, human-specific reagents can be used to perform WES for the discovery of genetic variants in these NHP species.","journal":"Journal of Medical Primatology","year":2021,"id":195453,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8921,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":766733,"name":"Wen Yao","orcid":"0000-0002-0643-506X","position":1,"is_corresponding":false},{"id":324237,"name":"Timothy D. Howard","orcid":"0000-0003-2518-4902","position":2,"is_corresponding":false},{"id":324562,"name":"Gregory A. Hawkins","orcid":null,"position":3,"is_corresponding":false},{"id":4580,"name":"Michael Olivier","orcid":"0000-0003-1632-1063","position":4,"is_corresponding":false},{"id":326697,"name":"Matthew J. Jorgensen","orcid":"0000-0002-0977-6425","position":5,"is_corresponding":false},{"id":562224,"name":"Ian H. Cheeseman","orcid":"0000-0003-4426-4027","position":6,"is_corresponding":false},{"id":246476,"name":"Shelley A. Cole","orcid":"0000-0002-2651-0127","position":7,"is_corresponding":false},{"id":275911,"name":"Laura A. Cox","orcid":"0000-0002-8836-3783","position":8,"is_corresponding":false},{"id":764216,"name":"Jeannie Chan","orcid":"0000-0003-4346-2873","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-18T23:50:07.691929Z","pmid":"33876458","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}