{"doi":"10.1111/jgs.19414","title":"Cancer and Accelerated Aging Research at the National Institutes of Health, 2013–2023: A Grant Portfolio Analysis","abstract":"BACKGROUND: The purpose of this study was to describe the characteristics of the NIH-funded grant portfolio focused on cancer and accelerated aging. METHODS: Research project grants focused on cancer survivors and aging trajectories that were newly funded during fiscal years 2013 through 2023 were identified by first using a text mining algorithm from the NIH Research, Condition, and Disease Categorization (RCDC) system with cancer survivorship-relevant terms and then a list of aging-related terms that included aging, neurocognition, and physical function. Included grants were double coded to extract study characteristics. RESULTS: A total of 166 grants were identified, with the National Cancer Institute (NCI) and National Institute on Aging (NIA) funding 62.0% and 23.5% of the grants, respectively. The number of newly funded grants rose from nine in 2013 to 27 in 2023. Overall, the majority were observational studies (65.1%); 45% included study samples of multiple cancer types. The most commonly examined outcomes were cognitive (54.4%) or physical (37.5%) functioning; 30% of grants incorporated an aging-related biomarker. Few grants focused on racial and ethnic minority (3.0%) or rural cancer survivors (2.4%). CONCLUSIONS: This portfolio analysis showed an increase in the number of NIH-funded grants focused on cancer survivors and accelerated aging, but notable gaps are evident. Given the rapidly growing survivor population, many of whom will experience accelerated aging trajectories, there is a critical need to better understand accelerated aging phenotypes and mechanisms, so that those at the highest risk for adverse aging-related effects can be identified and interventions developed.","journal":"Journal of the American Geriatrics Society","year":2025,"id":543193,"datarank":0.11152560405163224,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.007553526967640429,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.007553526967640429,"corpus_percentile":27.871896031561846,"corpus_rank":9323,"citation_count":1,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5629,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1122665,"name":"Rachelle Brick","orcid":"0000-0001-7099-7799","position":1,"is_corresponding":false},{"id":1232167,"name":"G Tesauro","orcid":null,"position":2,"is_corresponding":false},{"id":1298821,"name":"Lindsey L. Page","orcid":"0000-0001-9439-8520","position":3,"is_corresponding":false},{"id":278740,"name":"Paige Green","orcid":"0000-0001-7886-8924","position":4,"is_corresponding":false},{"id":278733,"name":"Jennifer Guida","orcid":"0000-0001-5590-5286","position":5,"is_corresponding":false},{"id":278739,"name":"Lisa Gallicchio","orcid":"0000-0001-7080-0140","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T02:53:04.088079Z","pmid":"39981626","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}