{"doi":"10.1111/jgs.17388","title":"Urine creatinine concentration and clinical outcomes in older adults: The Cardiovascular Health Study","abstract":"PURPOSE: Loss of muscle mass and strength are associated with long-term adverse health outcomes in older adults. Urine creatinine concentrations (Ucr; mg/dl) are a measure of muscle tissue mass and turnover. This study assessed the associations of a spot Ucr level with muscle mass and with risk of hospitalization, mortality, and diabetes mellitus in older adults. METHODS: We examined 3424 participants from the Cardiovascular Health Study who provided spot urine samples in 1996-1997 and who were followed through June 2015. All participants underwent baseline measurement of grip strength. In a sub-cohort, 1331 participants underwent dual energy X-ray absorptiometry (DEXA) scans, from which lean muscle mass was derived. Participants were followed for a median of 10 years for hospitalizations and mortality, and 9 years for diabetes mellitus. RESULTS: In linear regression analysis, a one standard deviation higher Ucr concentration (64.6 mg/dl) was associated with greater grip strength (kg force) β = 0.44 [0.16, 0.72]; p = 0.002) and higher lean muscle mass (kg) (β = 0.43 [0.08, 0.78]; p = 0.02). In Cox regression analyses, each standard deviation greater Ucr concentration was associated with lower rates of hospitalizations (0.94 [95% confidence interval, 0.90, 0.98]; p < 0.001) and lower mortality risk (0.92 [0.88, 0.97]; p < 0.001), while a one standard deviation increase in muscle mass derived from DEXA had no such significant association. Ucr levels were not associated with incident diabetes mellitus risk (0.97 [0.85, 1.11]; p = 0.65). CONCLUSION: A higher spot Ucr concentration was favorably associated with muscle mass and strength and with health outcomes in older community-living adults. The ease of obtaining a spot Ucr makes it an attractive analyte to use for gauging the health of older adults.","journal":"Journal of the American Geriatrics Society","year":2021,"id":209957,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7056,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":449335,"name":"Petra Bůžková","orcid":"0000-0001-8299-4974","position":1,"is_corresponding":false},{"id":19396,"name":"Michael G. Shlipak","orcid":"0000-0002-9559-204X","position":2,"is_corresponding":false},{"id":404670,"name":"Mary F. Lyles","orcid":"0000-0002-7741-1356","position":3,"is_corresponding":false},{"id":54242,"name":"Nisha Bansal","orcid":"0000-0002-9583-8628","position":4,"is_corresponding":false},{"id":707463,"name":"Pranav S. Garimella","orcid":"0000-0002-6016-4715","position":5,"is_corresponding":false},{"id":261907,"name":"Joachim H. Ix","orcid":"0000-0002-8084-9869","position":6,"is_corresponding":false},{"id":246786,"name":"Jorge R. Kizer","orcid":"0000-0001-9936-7803","position":7,"is_corresponding":false},{"id":341578,"name":"Elsa S. Strotmeyer","orcid":"0000-0002-4093-6036","position":8,"is_corresponding":false},{"id":98937,"name":"Luc Djoussé","orcid":"0000-0002-9902-3047","position":9,"is_corresponding":false},{"id":442178,"name":"Mary L. Biggs","orcid":"0000-0003-0687-9610","position":10,"is_corresponding":false},{"id":267326,"name":"David S. Siscovick","orcid":"0000-0003-0461-175X","position":11,"is_corresponding":false},{"id":291349,"name":"Kenneth J. Mukamal","orcid":"0000-0001-8450-6970","position":12,"is_corresponding":false},{"id":738638,"name":"Joshua I. Barzilay","orcid":"0000-0001-7044-4166","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-18T23:52:08.869117Z","pmid":"34363689","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}