{"doi":"10.1111/jgh.16828","title":"Association Between Triglyceride‐Glucose Index and Risk of Gallstone Disease: A Prospective Cohort Study of 395 391 Individuals","abstract":"<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>Gallstone disease (GSD) is one of the widespread gastrointestinal conditions. Triglyceride‐glucose (TyG) index, a convenient surrogate for insulin resistance, may help identify and prevent gallstones. The present study aims to conduct a longitudinal study to evaluate the association between TyG index and the risk of GSD using the UK Biobank cohort.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>A total of 395 391 participants in the UK Biobank (median follow‐up of 12.52 years) were included. The association between TyG index and the risk of GSD was assessed through Cox models and the restricted cubic spline model, expressed by hazard ratios (HRs) and 95% confidence intervals (CIs). Subgroup analysis was employed concerning age, gender, and body mass index (BMI) and also analyzed the mediating role of BMI in the effect of TyG index on incident GSD. Sensitivity analyses were further performed using a competing risks model and excluding participants who developed GSD in the first year of follow‐up to test the stability of the results.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The risk of developing GSD increased in the Quartiles 2, 3, and 4 compared with Quartile 1 of TyG index (adjusted HR [aHR] 1.570 [95%CI 1.303–1.893], 1.577 [1.295–1.920], 1.489 [1.181–1.878], <jats:italic>P</jats:italic><jats:sub>trend</jats:sub> &lt; 0.001 across quartiles of TyG index). The aHR for every unit and SD increment in TyG index were 1.282 [1.100–1.494], 1.151 [1.055–1.256]. The results were consistent when participants who developed GSD in the first year of follow‐up were excluded. The restricted cubic spline regression also showed an increased risk of GSD with increasing TyG index.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Increased TyG index is associated with an elevated risk of GSD. The TyG index might be an important indicator for identifying people at high risk of GSD.</jats:p></jats:sec>","journal":"Journal of Gastroenterology and Hepatology","year":2025,"id":605743,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1554718,"name":"Guoheng Jiang","orcid":null,"position":1,"is_corresponding":false},{"id":1257353,"name":"Wenqian Yu","orcid":"0009-0009-0411-309X","position":2,"is_corresponding":false},{"id":409381,"name":"Jing Luo","orcid":"0000-0001-6483-4264","position":3,"is_corresponding":false},{"id":1459495,"name":"Shiyi Li","orcid":"0000-0002-1650-3249","position":4,"is_corresponding":false},{"id":1353573,"name":"Linjun Xie","orcid":"0000-0002-4048-3954","position":5,"is_corresponding":false},{"id":1554723,"name":"Xuan Bai","orcid":null,"position":6,"is_corresponding":false},{"id":719557,"name":"Yiting Xu","orcid":"0009-0005-0890-5626","position":7,"is_corresponding":false},{"id":491584,"name":"Yi Jiang","orcid":"0000-0002-7519-6365","position":8,"is_corresponding":false},{"id":1554727,"name":"Menglin He","orcid":null,"position":9,"is_corresponding":false},{"id":683340,"name":"Jin Zhou","orcid":"0000-0001-8121-4198","position":10,"is_corresponding":false},{"id":1069848,"name":"Xin Wang","orcid":"0000-0001-9325-3194","position":11,"is_corresponding":false},{"id":572277,"name":"Hongyu Li","orcid":"0000-0001-6525-9310","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Association Between Triglyceride‐Glucose Index and Risk of Gallstone Disease: A Prospective Cohort Study of 395 391 Individuals","abstract":"<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>Gallstone disease (GSD) is one of the widespread gastrointestinal conditions. Triglyceride‐glucose (TyG) index, a convenient surrogate for insulin resistance, may help identify and prevent gallstones. The present study aims to conduct a longitudinal study to evaluate the association between TyG index and the risk of GSD using the UK Biobank cohort.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>A total of 395 391 participants in the UK Biobank (median follow‐up of 12.52 years) were included. The association between TyG index and the risk of GSD was assessed through Cox models and the restricted cubic spline model, expressed by hazard ratios (HRs) and 95% confidence intervals (CIs). Subgroup analysis was employed concerning age, gender, and body mass index (BMI) and also analyzed the mediating role of BMI in the effect of TyG index on incident GSD. Sensitivity analyses were further performed using a competing risks model and excluding participants who developed GSD in the first year of follow‐up to test the stability of the results.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The risk of developing GSD increased in the Quartiles 2, 3, and 4 compared with Quartile 1 of TyG index (adjusted HR [aHR] 1.570 [95%CI 1.303–1.893], 1.577 [1.295–1.920], 1.489 [1.181–1.878], <jats:italic>P</jats:italic><jats:sub>trend</jats:sub> &lt; 0.001 across quartiles of TyG index). The aHR for every unit and SD increment in TyG index were 1.282 [1.100–1.494], 1.151 [1.055–1.256]. The results were consistent when participants who developed GSD in the first year of follow‐up were excluded. The restricted cubic spline regression also showed an increased risk of GSD with increasing TyG index.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Increased TyG index is associated with an elevated risk of GSD. The TyG index might be an important indicator for identifying people at high risk of GSD.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39644177","pmcid":"PMC11807791","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81903398","title":null},{"funder_name":"Natural Science Foundation of Sichuan Province","grant_id":"2023NSFSC1927","title":null},{"funder_name":"Sichuan Provincial Science and Technology Department 2023 Central Guide Local Project","grant_id":"2023ZYD0097","title":null},{"funder_name":"Medical Youth Innovation research project of Sichuan Province","grant_id":"Q21016","title":null},{"funder_name":"The research start-up fund for the introduction of talents of Sichuan University","grant_id":"YJ2021112","title":null},{"funder_name":"\"From 0 to 1\" Innovation Project, Sichuan University","grant_id":"2023SCUH0026","title":null}],"total_grants":6,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jgh.16828","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jgh.16828","host_type":"publisher"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11807791/pdf/JGH-40-404.pdf","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11807791","host_type":"Unpaywall"},{"url":"https://europepmc.org/articles/PMC11807791","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11807791?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":["Humans","Insulin Resistance","Gallstones","Blood Glucose","Triglycerides","Body Mass Index","Incidence","Risk Assessment","Risk Factors","Longitudinal Studies","Follow-Up Studies","Prospective Studies","Adult","Aged","Middle Aged","Female","Male","Biomarkers","United Kingdom"],"keywords":["Insulin resistance","Gallstone Disease","Uk Biobank","Triglyceride‐Glucose Index"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T03:07:51.119793Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}