{"doi":"10.1111/jgh.16498","title":"The impact of sodium‐glucose cotransporter‐2 inhibitors on outcome of patients with diabetes mellitus and colorectal cancer","abstract":"BACKGROUND AND AIM: Patients with type 2 diabetes mellitus (T2DM) have a higher risk of colorectal cancer (CRC), and those with diagnosed CRC have a poorer prognosis compared with individuals with normal glucose levels. The inhibition of sodium-glucose cotransporter 2 (SGLT2) channels has been associated with a reduction in tumor proliferation in preclinical studies. We aimed to investigate the impact of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on the outcome of T2DM patients with colorectal cancer. METHODS: We performed a retrospective cohort study comprising adult patients with T2DM and colorectal adenocarcinoma. SGLT2i recipients were matched to non-SGLT2i recipients in a 1:1 ratio based on age, sex, and cancer stage. The primary outcome was overall survival (OS) and progression-free survival (PFS), and the secondary outcomes were previously reported serious adverse events associated with SGLT2i. RESULTS: We identified 1347 patients with T2DM and colorectal adenocarcinoma, from which 92 patients in the SGLT2i cohort were matched to the non-SGLT2i cohort. Compared to non-SGLT2i recipients, SGLT2i recipients had a higher rate of 5-year OS (86.2% [95% CI: 72.0-93.5] vs 62.3% [95% CI: 50.9-71.8], P = 0.013) and 5-year PFS (76.6% [95% CI: 60.7-86.7] vs 57.0% [95% CI: 46.2-66.4], P = 0.021). In Cox proportional hazard analyses, SGLT2i were associated with a 50-70% reduction in all-cause mortality and disease progression. SGLT2i were not associated with an increased risk of serious adverse events. CONCLUSION: SGLT2i were associated with a higher rate of survival in T2DM patients with colorectal cancer.","journal":"Journal of Gastroenterology and Hepatology","year":2024,"id":422891,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":859457,"name":"Cho‐Hung Chiang","orcid":"0000-0002-7910-2338","position":2,"is_corresponding":false},{"id":860071,"name":"Yuan Ping Hsia","orcid":null,"position":4,"is_corresponding":false},{"id":1217377,"name":"Aunchalee Jaroenlapnopparat","orcid":"0000-0001-6716-5967","position":5,"is_corresponding":false},{"id":859461,"name":"Chuan‐Sheng Horng","orcid":"0000-0002-0909-1776","position":6,"is_corresponding":false},{"id":1217378,"name":"Kit Yee Wong","orcid":"0000-0003-2744-7761","position":7,"is_corresponding":false},{"id":860075,"name":"Shih‐Syuan Wang","orcid":null,"position":8,"is_corresponding":false},{"id":882033,"name":"Yung‐Chun Chang","orcid":"0000-0002-9634-8380","position":9,"is_corresponding":false},{"id":1217379,"name":"Brian Shiian Chen","orcid":"0000-0001-5068-9457","position":10,"is_corresponding":false},{"id":1217380,"name":"Yu‐Ze Luan","orcid":"0000-0003-2098-7183","position":11,"is_corresponding":false},{"id":1217381,"name":"Chun‐Hao Wang","orcid":"0000-0002-0180-7207","position":12,"is_corresponding":false},{"id":232198,"name":"Tomas G. Neilan","orcid":"0000-0002-1513-8833","position":13,"is_corresponding":false},{"id":859458,"name":"Cho‐Hsien Chiang","orcid":"0000-0002-1744-9141","position":14,"is_corresponding":false},{"id":859463,"name":"Cheng‐Ming Peng","orcid":"0000-0002-7817-0830","position":16,"is_corresponding":false},{"id":860077,"name":"Her‐Shyong Shiah","orcid":null,"position":17,"is_corresponding":false},{"id":859456,"name":"Cho‐Han Chiang","orcid":"0000-0002-5757-6161","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T01:57:51.642883Z","pmid":"38296226","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}