{"doi":"10.1111/jcpe.14067","title":"Association Between Dietary Patterns and Subgingival Microbiota: Results From the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (<scp>ORIGINS</scp>)","abstract":"OBJECTIVE: To study the association between dietary patterns and subgingival microbiota. METHODS: Participants (n = 651) who were enrolled in the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (ORIGINS) with subgingival plaque sampling (n = 890 plaques) and a dietary assessment were included. 16S rRNA gene amplicon sequences of subgingival plaque from sites with either probing depth <4 or ≥4 mm were processed separately and used to obtain α-diversity metrics (Faith, Shannon, Simpson, Observed) and taxa ratios (Red Complex to Corynebacterium [RCLR], Treponema to Corynebacterium [TCLR], and Treponema to Neisseria [TNLR]). Food frequency questionnaires (FFQs) were processed to calculate Alternate Healthy Eating Index (AHEI) and A Priori Diet Quality Score (APDQS) scores. Mixed regression models examined the mean levels of microbial metrics across quartiles of diet quality. Means ± standard errors are reported along with p-values. RESULTS: In multivariable models assessing the association between diet scores and α-diversity metrics, higher AHEI values were significantly associated with lower Faith (p-value = 0.01) and Observed (p-value = 0.04) diversity values; similar findings were observed for APDQS (p-value = 0.01, p-value = 0.04). In multivariable models assessing the association between diet scores (AHEI and APDQS) and taxa ratios (RCLR, TCLR and TNLR), as the AHEI quartile increased, all taxa ratios decreased significantly as follows: -1.06 ± 0.093 in Q1 to -1.34 ± 0.099 in Q4 (RCLR), -0.43 ± 0.077 in Q1 to -0.64 ± 0.083 in Q4 (TCLR) and -0.09 ± 0.083 in Q1 to -0.38 ± 0.089 in Q4 (TNLR), respectively. In contrast, as the APDQS quartiles increased, only TNLR decreased significantly from -0.08 ± 0.085 in Q1 to -0.34 ± 0.091 in Q4. CONCLUSION: Diets rich in fruits, vegetables, whole grains and other nutritionally rich plant foods are associated with lower oral microbial diversity and favourable ratios of pathogenic to commensal microbiota.","journal":"Journal Of Clinical Periodontology","year":2024,"id":445710,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5723,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":256656,"name":"Abigail J. Johnson","orcid":"0000-0002-5998-4724","position":1,"is_corresponding":false},{"id":1262557,"name":"Lisa Marotz","orcid":null,"position":2,"is_corresponding":false},{"id":461691,"name":"Sumith Roy","orcid":"0000-0002-8887-9835","position":3,"is_corresponding":false},{"id":271770,"name":"Bruno Bohn","orcid":"0000-0001-8961-6968","position":4,"is_corresponding":false},{"id":1262094,"name":"Charlene Enhui Goh","orcid":"0000-0002-2208-5397","position":5,"is_corresponding":false},{"id":1262558,"name":"Ching‐Yuan Chen","orcid":null,"position":6,"is_corresponding":false},{"id":537660,"name":"Bruce J. Paster","orcid":"0000-0002-5872-1906","position":7,"is_corresponding":false},{"id":3554,"name":"Rob Knight","orcid":"0000-0002-0975-9019","position":8,"is_corresponding":false},{"id":246242,"name":"Jeanine M. Genkinger","orcid":"0000-0002-8438-0412","position":9,"is_corresponding":false},{"id":245678,"name":"Panos N. Papapanou","orcid":"0000-0002-6538-3618","position":10,"is_corresponding":false},{"id":65159,"name":"DAVID R. JACOBS","orcid":"0000-0002-7232-0543","position":11,"is_corresponding":false},{"id":36326,"name":"Ryan T. Demmer","orcid":"0000-0003-3429-0379","position":12,"is_corresponding":false},{"id":747340,"name":"Rebecca Molinsky","orcid":"0000-0001-9564-0147","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T02:01:46.243344Z","pmid":"39394967","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}