{"doi":"10.1111/jcpe.13945","title":"Clinical attachment loss is cross‐sectionally associated with elevated glucose among adults without diabetes","abstract":"AIM: We investigated whether periodontal measures are cross-sectionally associated with prediabetes and cardiometabolic biomarkers among non-diabetic younger adults. MATERIALS AND METHODS: One thousand seventy-one participants (mean age = 32.2 years [SE = 0.3]; 73% female) from the Oral Infections, Glucose Intolerance and Insulin Resistance Study were enrolled. Full-mouth clinical attachment loss (fm-CAL), probing depth (fm-PD) and bleeding on probing were ascertained. Interproximal CAL (i-CAL) and probing depths (i-PD) served as our primary exposures. Glucose, HbA1c, insulin and insulin resistance (HOMA-IR) outcomes were assessed from fasting blood. Prediabetes was defined per American Diabetes Association guidelines. Prediabetes prevalence ratios (PR [95% CI]) and mean [SE] cardiometabolic biomarkers were regressed on periodontal variables via multivariable robust variance Poisson regression or multivariable linear regression. RESULTS: Prevalence of prediabetes was 12.5%. Fully adjusted prediabetes PR in Tertiles 3 versus 1 of mean i-CAL was 2.42 (1.77, 3.08). Fully adjusted fasting glucose estimates across i-CAL tertiles were 83.29 [0.43], 84.31 [0.37], 86.48 [0.46]; p for trend <.01. Greater percent of sites with i-PD ≥3 mm showed elevated natural-log-HOMA-IR after adjustment (0%-12% of sites = 0.33 [0.03], 13%-26% of sites = 0.39 [0.03], ≥27% of sites = 0.42 [0.03]; p for trend = .04). CONCLUSIONS: i-CAL (vs. fm-CAL) was associated with elevated fasting glucose and prediabetes, whereas i-PD (vs. fm-PD) was associated with insulin resistance. Future studies are needed to examine periodontal disease and incident prediabetes.","journal":"Journal Of Clinical Periodontology","year":2024,"id":463627,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8298,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":747340,"name":"Rebecca Molinsky","orcid":"0000-0001-9564-0147","position":1,"is_corresponding":false},{"id":271770,"name":"Bruno Bohn","orcid":"0000-0001-8961-6968","position":2,"is_corresponding":false},{"id":461691,"name":"Sumith Roy","orcid":"0000-0002-8887-9835","position":3,"is_corresponding":false},{"id":2963,"name":"Michael Rosenbaum","orcid":"0000-0002-8908-9448","position":4,"is_corresponding":false},{"id":537660,"name":"Bruce J. Paster","orcid":"0000-0002-5872-1906","position":5,"is_corresponding":false},{"id":271769,"name":"M. Yuzefpolskaya","orcid":"0000-0003-4729-8943","position":6,"is_corresponding":false},{"id":271781,"name":"P.C. Colombo","orcid":"0000-0003-4977-3285","position":7,"is_corresponding":false},{"id":245678,"name":"Panos N. Papapanou","orcid":"0000-0002-6538-3618","position":8,"is_corresponding":false},{"id":888926,"name":"Moı̈se Desvarieux","orcid":null,"position":9,"is_corresponding":false},{"id":65159,"name":"DAVID R. JACOBS","orcid":"0000-0002-7232-0543","position":10,"is_corresponding":false},{"id":36326,"name":"Ryan T. Demmer","orcid":"0000-0003-3429-0379","position":11,"is_corresponding":false},{"id":668983,"name":"Hamdi S Adam","orcid":"0000-0001-9655-7628","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:04:33.257852Z","pmid":"38343130","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}