{"doi":"10.1111/jcmm.70686","title":"Robust Increase in <scp>IQCK</scp> Protein Expression in Mouse Models of Alzheimer's Disease and <scp>iPSC</scp>‐Derived Neurons","abstract":"Emerging studies indicate that the IQ-motif-containing protein K (IQCK) is a novel risk factor for Alzheimer's disease (AD), an age-associated disease. The expression patterns of IQCK in healthy and AD brains, within the context of age and sex are largely unknown. Therefore, we compared the age-dependent expression patterns of IQCK in males and females of wild-type (WT) mice with AD-like 3xTg and APΔE9 mice. Additionally, we measured IQCK protein expression in AD-derived human iPSC neurons. In WT mice, we found no IQCK expression at day 1 (1D) in the cortex (CX), hippocampus (HP), brainstem (BS) and cerebellum (CB). Overall, IQCK protein expression in different brain regions was first detected in 1-month-old wild-type (WT) mice, reaching its maximum in 1-year-old mice (1Y), and then gradually decreased in 2-year-old mice. In the APΔE9 mice, IQCK protein levels significantly increased by 1246% in the CX, 682% in the HP and 169% in the BS relative to WT controls. In the 3xTg mice, only HP showed an increase of IQCK protein by 277%. In addition, we also detected elevated tendencies in BS and CB regions but not in the CX. Finally, IQCK expression was also significantly increased by 68% in the AD-derived iPSC neurons relative to the NC-derived iPSC neurons. Thus, increased IQCK protein levels in the brain of AD-like 3xTg and APΔE9 mouse models suggest a possible role in AD pathogenesis, a finding that requires further clarification.","journal":"Journal of Cellular and Molecular Medicine","year":2025,"id":541656,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9613,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":294141,"name":"Dinesh Devadoss","orcid":"0000-0003-0069-1799","position":1,"is_corresponding":false},{"id":309007,"name":"Hongjie Wang","orcid":"0000-0002-4359-5417","position":2,"is_corresponding":false},{"id":340459,"name":"Alexandru Movilă","orcid":"0000-0001-9827-7347","position":3,"is_corresponding":false},{"id":490136,"name":"Madepalli K. Lakshmana","orcid":"0000-0002-1291-4438","position":4,"is_corresponding":false},{"id":340456,"name":"Juliet Akkaoui","orcid":"0000-0003-1716-4928","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-19T02:52:47.161928Z","pmid":"40604342","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}