{"doi":"10.1111/jcmm.70634","title":"<scp>OVOL1</scp>\n                    Promotes Proliferation and Metastasis of Non‐Small Cell Lung Cancer by Regulating\n                    <scp>APOE</scp>\n                    ‐Mediated Cholesterol Metabolism","abstract":"<jats:title>ABSTRACT</jats:title>\n                  <jats:p>Non‐small cell lung cancer (NSCLC) is a highly lethal malignant tumour characterised by its resistance to treatment, often due to metabolic reprogramming. Despite this, the underlying mechanisms by which aberrant cholesterol metabolism influences the development and progression of NSCLC remain unclear. In our study, we observed that OVOL1 is significantly upregulated in NSCLC and is correlated with a poor prognosis. Furthermore, our functional assays revealed that OVOL1 enhances the proliferation and metastasis of NSCLC cells both in vitro and in vivo. Mechanistically, OVOL1 was found to modulate cholesterol reprogramming and increase the expression of APOE, thereby intensifying cholesterol metabolism and facilitating cell migration and invasion. In conclusion, our findings suggest that OVOL1 acts as an oncogene in NSCLC, promoting tumour growth and metastasis through the enhancement of cholesterol metabolism. This underscores the potential of OVOL1 as a therapeutic target for the treatment of NSCLC.</jats:p>","journal":"Journal of Cellular and Molecular Medicine","year":2025,"id":626209,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":440096,"name":"Li Zhang","orcid":"0000-0003-0006-4066","position":1,"is_corresponding":false},{"id":1619791,"name":"Teng Sun","orcid":null,"position":2,"is_corresponding":false},{"id":1180533,"name":"Lei Xu","orcid":"0000-0001-8280-3162","position":3,"is_corresponding":false},{"id":1619793,"name":"Xiaoyu Quan","orcid":null,"position":4,"is_corresponding":false},{"id":1619794,"name":"Guoqing Zhao","orcid":null,"position":5,"is_corresponding":false},{"id":397857,"name":"Hao Zhang","orcid":"0000-0002-2049-3485","position":6,"is_corresponding":false},{"id":1619789,"name":"Shoujie Feng","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"<scp>OVOL1</scp>\n                    Promotes Proliferation and Metastasis of Non‐Small Cell Lung Cancer by Regulating\n                    <scp>APOE</scp>\n                    ‐Mediated Cholesterol Metabolism","abstract":"<jats:title>ABSTRACT</jats:title>\n                  <jats:p>Non‐small cell lung cancer (NSCLC) is a highly lethal malignant tumour characterised by its resistance to treatment, often due to metabolic reprogramming. Despite this, the underlying mechanisms by which aberrant cholesterol metabolism influences the development and progression of NSCLC remain unclear. In our study, we observed that OVOL1 is significantly upregulated in NSCLC and is correlated with a poor prognosis. Furthermore, our functional assays revealed that OVOL1 enhances the proliferation and metastasis of NSCLC cells both in vitro and in vivo. Mechanistically, OVOL1 was found to modulate cholesterol reprogramming and increase the expression of APOE, thereby intensifying cholesterol metabolism and facilitating cell migration and invasion. In conclusion, our findings suggest that OVOL1 acts as an oncogene in NSCLC, promoting tumour growth and metastasis through the enhancement of cholesterol metabolism. This underscores the potential of OVOL1 as a therapeutic target for the treatment of NSCLC.</jats:p>","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40437660","pmcid":"PMC12119240","openalex_id":"https://openalex.org/W4410873517","authors":[],"funders":[{"funder_name":"the Project supported by the Affiliated Hospital of Xuzhou Medical University","grant_id":"2021ZA05","title":null},{"funder_name":"the Social Development Projects of Key R&amp;D Programs in Xuzhou city","grant_id":"KC22252","title":null}],"total_grants":2,"fwci":0.9381,"citation_percentile":0.73595868,"influential_citations":0,"citation_trend":[{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.70634","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.70634","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jcmm.70634","host_type":"publisher"},{"url":"https://doi.org/10.1111/jcmm.70634","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40437660","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12119240","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12119240","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12119240?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cancer, Lipids, and Metabolism","ATP Synthase and ATPases Research","Cholesterol and Lipid Metabolism","Humans","Carcinoma, Non-Small-Cell Lung","Cholesterol","Cell Proliferation","Lung Neoplasms","Animals","Cell Movement","Cell Line, Tumor","Apolipoproteins E","Mice","Gene Expression Regulation, Neoplastic","Female","Neoplasm Metastasis","Male","Mice, Nude","Prognosis"],"mesh_terms":["Animals","Apolipoproteins E","Carcinoma, Non-Small-Cell Lung","Cell Movement","Cholesterol","Female","Humans","Lung Neoplasms","Male","Mice, Nude","Neoplasm Metastasis","Prognosis","Gene Expression Regulation, Neoplastic","Cell Line, Tumor","Cell Proliferation","Mice"],"keywords":["Metastasis","Cancer research","Downregulation and upregulation","Lung cancer","Cell growth","Reprogramming","Biology","Cholesterol","Oncogene","Lipid metabolism","Cell","In vivo","Cancer","Internal medicine","Medicine","Endocrinology","Cell cycle","Biochemistry","Metabolism"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"No poverty"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T12:52:21.068492Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}