{"doi":"10.1111/jcmm.17246","title":"Identification of natural compounds tubercidin and lycorine HCl against small‐cell lung cancer and BCAT1 as a therapeutic target","abstract":"Although small-cell lung cancer (SCLC) accounts for a small fraction of lung cancer cases (~15%), the prognosis of patients with SCLC is poor with an average overall survival period of a few months without treatment. Current treatments include standard chemotherapy, which has minimal efficacy and a newly developed immunotherapy that thus far, benefits a limited number of patients. In the current study, we screened a natural product library and identified 5 natural compounds, in particular tubercidin and lycorine HCl, that display prominent anti-SCLC activities in vitro and in vivo. Subsequent RNA-sequencing and functional validation assays revealed the anti-SCLC mechanisms of these new compounds, and further identified new cellular factors such as BCAT1 as a potential therapeutic target with clinical implication in SCLC patients. Taken together, our study provides promising new directions for fighting this aggressive lung cancer.","journal":"Journal of Cellular and Molecular Medicine","year":2022,"id":269198,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":343154,"name":"Lindsey Barrett","orcid":null,"position":1,"is_corresponding":false},{"id":135946,"name":"Zhen Lin","orcid":"0000-0002-9229-053X","position":2,"is_corresponding":false},{"id":488295,"name":"Samantha Kendrick","orcid":"0000-0002-7782-7415","position":3,"is_corresponding":false},{"id":407313,"name":"Shengyu Mu","orcid":"0000-0001-9368-7881","position":4,"is_corresponding":false},{"id":341607,"name":"Lu Dai","orcid":"0000-0002-6818-8535","position":5,"is_corresponding":false},{"id":341608,"name":"Zhiqiang Qin","orcid":"0000-0002-9905-1275","position":6,"is_corresponding":false},{"id":341606,"name":"Jungang Chen","orcid":"0000-0002-5429-7079","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T00:27:18.142851Z","pmid":"35318805","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}