{"doi":"10.1111/jcmm.17045","title":"Caveolin‐1 negatively regulates inflammation and fibrosis in silicosis","abstract":"<jats:title>Abstract</jats:title><jats:p>Inhalation of crystalline silica causes silicosis, the most common and serious occupational disease, which is characterized by progressive lung inflammation and fibrosis. Recent studies revealed the anti‐inflammatory and anti‐fibrosis role of Caveolin‐1 (Cav‐1) in lung, but this role in silicosis has not been investigated. Thus, this study evaluated Cav‐1 regulatory effects in silicosis. It was found that Cav‐1 levels were significantly reduced in the lung from silicosis patients and silicotic mice. The silicosis models were established in C57BL/6 (wild‐type) and Cav‐1 deficiency (<jats:italic>Cav</jats:italic>‐<jats:italic>1</jats:italic><jats:sup>−/−</jats:sup>) mice, and <jats:italic>Cav</jats:italic>‐<jats:italic>1</jats:italic><jats:sup>−/−</jats:sup> mice displayed wider alveolar septa, increased collagen deposition and more silicotic nodules. The mice peritoneal‐derived macrophages were used to explore the role of Cav‐1 in silica‐induced inflammation, which plays a central role in mechanism of silicosis. Cav‐1 inhibited silica‐induced infiltration of inflammatory cells and secretion of inflammatory factors in vitro and in vivo, partly by downregulating NF‐κB pathway. Additionally, silica uptake and expression of 4‐hydroxynonenal in silicotic mice were observed, and it was found that Cav‐1 absence triggered excessive silica deposition, causing a stronger oxidative stress response. These findings demonstrate the protective effects of Cav‐1 in silica‐induced lung injury, suggesting its potential therapeutic value in silicosis.</jats:p>","journal":"Journal of Cellular and Molecular Medicine","year":2022,"id":676728,"datarank":0.5495342469194471,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":0.0,"self_endowment_contribution":0.5495342469194471,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1768152,"name":"XiangNing Yuan","orcid":null,"position":1,"is_corresponding":false},{"id":1354112,"name":"Xin Lv","orcid":"0000-0002-3352-7162","position":2,"is_corresponding":false},{"id":1768161,"name":"QingXiang Liu","orcid":null,"position":3,"is_corresponding":false},{"id":1768164,"name":"LiJian Tao","orcid":null,"position":4,"is_corresponding":false},{"id":417800,"name":"Jie Meng","orcid":"0000-0002-6367-0568","position":5,"is_corresponding":false},{"id":1768147,"name":"RongLing He","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Caveolin‐1 negatively regulates inflammation and fibrosis in silicosis","abstract":"<jats:title>Abstract</jats:title><jats:p>Inhalation of crystalline silica causes silicosis, the most common and serious occupational disease, which is characterized by progressive lung inflammation and fibrosis. Recent studies revealed the anti‐inflammatory and anti‐fibrosis role of Caveolin‐1 (Cav‐1) in lung, but this role in silicosis has not been investigated. Thus, this study evaluated Cav‐1 regulatory effects in silicosis. It was found that Cav‐1 levels were significantly reduced in the lung from silicosis patients and silicotic mice. The silicosis models were established in C57BL/6 (wild‐type) and Cav‐1 deficiency (<jats:italic>Cav</jats:italic>‐<jats:italic>1</jats:italic><jats:sup>−/−</jats:sup>) mice, and <jats:italic>Cav</jats:italic>‐<jats:italic>1</jats:italic><jats:sup>−/−</jats:sup> mice displayed wider alveolar septa, increased collagen deposition and more silicotic nodules. The mice peritoneal‐derived macrophages were used to explore the role of Cav‐1 in silica‐induced inflammation, which plays a central role in mechanism of silicosis. Cav‐1 inhibited silica‐induced infiltration of inflammatory cells and secretion of inflammatory factors in vitro and in vivo, partly by downregulating NF‐κB pathway. Additionally, silica uptake and expression of 4‐hydroxynonenal in silicotic mice were observed, and it was found that Cav‐1 absence triggered excessive silica deposition, causing a stronger oxidative stress response. These findings demonstrate the protective effects of Cav‐1 in silica‐induced lung injury, suggesting its potential therapeutic value in silicosis.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34889029","pmcid":"PMC8742238","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81470255","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82070070","title":null}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1111/jcmm.17045","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jcmm.17045","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jcmm.17045","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8742238","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8742238","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8742238?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":["Lung","Animals","Mice, Inbred C57BL","Humans","Mice","Silicosis","Pulmonary Fibrosis","Disease Models, Animal","Fibrosis","Inflammation","Silicon Dioxide","Caveolin 1"],"keywords":["Silicosis","Inflammation","fibrosis","Caveolin-1"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T03:01:12.991073Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}