{"doi":"10.1111/jcmm.15260","title":"Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender‐specific changes in the microRNA expression profiling in ME/CFS","abstract":"Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem illness characterized by medically unexplained debilitating fatigue with suggested altered immunological state. Our study aimed to explore peripheral blood mononuclear cells (PBMCs) for microRNAs (miRNAs) expression in ME/CFS subjects under an exercise challenge. The findings highlight the immune response and inflammation links to differential miRNA expression in ME/CFS. The present study is particularly important in being the first to uncover the differences that exist in miRNA expression patterns in males and females with ME/CFS in response to exercise. This provides new evidence for the understanding of differential miRNA expression patterns and post-exertional malaise in ME/CFS. We also report miRNA expression pattern differences associating with the nutritional status in individuals with ME/CFS, highlighting the effect of subjects' metabolic state on molecular changes to be considered in clinical research within the NINDS/CDC ME/CFS Common Data Elements. The identification of gender-based miRNAs importantly provides new insights into gender-specific ME/CFS susceptibility and demands exploration of sex-suited ME/CFS therapeutics.","journal":"Journal of Cellular and Molecular Medicine","year":2020,"id":96427,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9482,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":478384,"name":"Leonor Sarría","orcid":null,"position":1,"is_corresponding":false},{"id":478385,"name":"Mina Bekheit","orcid":null,"position":2,"is_corresponding":false},{"id":478386,"name":"Fanny Collado","orcid":null,"position":3,"is_corresponding":false},{"id":478387,"name":"Eloy Almenar‐Pérez","orcid":null,"position":4,"is_corresponding":false},{"id":478388,"name":"Eva Martín‐Martínez","orcid":null,"position":5,"is_corresponding":false},{"id":477764,"name":"José Alegre","orcid":"0000-0002-7582-7585","position":6,"is_corresponding":false},{"id":463173,"name":"Jesús Castro‐Marrero","orcid":"0000-0002-2481-3052","position":7,"is_corresponding":false},{"id":478389,"name":"Mary A Fletcher","orcid":null,"position":8,"is_corresponding":false},{"id":329994,"name":"Nancy G. Klimas","orcid":"0000-0003-1459-3268","position":9,"is_corresponding":false},{"id":477765,"name":"Elisa Oltra","orcid":"0000-0003-0598-2907","position":10,"is_corresponding":false},{"id":477766,"name":"Lubov Nathanson","orcid":"0000-0003-1038-9083","position":11,"is_corresponding":false},{"id":477763,"name":"Amanpreet Cheema","orcid":"0000-0003-4402-7179","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-18T22:34:34.781847Z","pmid":"32291908","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}