{"doi":"10.1111/jcmm.14372","title":"Effect of local aromatase inhibition in endometriosis using a new chick embryo chorioallantoic membrane model","abstract":"<jats:title>Abstract</jats:title><jats:p>Endometriosis is an oestrogen‐dependent, inflammation‐driven gynaecologic disorder causing severe disability. Endometriosis implants are characterized by unbalanced local oestrogen metabolism leading to hyperoestrogenism and aromatase up‐regulation is one of main mechanism involved. Aromatase inhibitors such as letrozole or anastrozole use in young women are associated with severely side effects limiting their long‐term clinical use. An endometriosis‐targeted inhibition of local aromatase could be a viable alternative, although the role of the local inhibition of this enzyme is still unclear. Using a new chick embryo allantoic membrane (CAM) model incorporating xenografted human endometriosis cyst, we showed that topical treatment with anastrozole reduced lesion size, although oestrogens produced by CAM female embryo blunted this effect. Xenografted human endometriosis CAM is a new efficient model for the screening of new drugs targeting endometriosis tissue.</jats:p>","journal":"Journal of Cellular and Molecular Medicine","year":2019,"id":37005,"datarank":0.6805272288674633,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.2469714651830386,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.2469714651830386,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":14,"citers_with_citation_signal":10,"citers_with_endowment":10,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":186312,"name":"Giorgia Poppi","orcid":null,"position":1,"is_corresponding":false},{"id":186313,"name":"Lucile Yart","orcid":null,"position":2,"is_corresponding":false},{"id":186314,"name":"Roberto Marci","orcid":null,"position":3,"is_corresponding":false},{"id":186315,"name":"Jean‐Marie Wenger","orcid":null,"position":4,"is_corresponding":false},{"id":186316,"name":"Jean‐Christophe Tille","orcid":null,"position":5,"is_corresponding":false},{"id":186317,"name":"Marie Cohen","orcid":null,"position":6,"is_corresponding":false},{"id":186311,"name":"Nicola Pluchino","orcid":"0000-0002-7475-9082","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31199588","pmcid":"PMC6653393","openalex_id":"https://openalex.org/W2951249702","authors":[],"funders":[],"total_grants":0,"fwci":2.0006,"citation_percentile":0.86001577,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":3},{"year":2022,"count":5},{"year":2023,"count":3},{"year":2024,"count":1},{"year":2025,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.14372","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.14372","host_type":"GOLD"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.14372","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjcmm.14372","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jcmm.14372","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jcmm.14372","host_type":"publisher"},{"url":"https://doi.org/10.1111/jcmm.14372","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31199588","host_type":"repository"},{"url":"https://archive-ouverte.unige.ch/unige:123524","host_type":"repository"},{"url":"http://hdl.handle.net/11392/2418474","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6653393","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6653393","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6653393?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Endometriosis Research and Treatment","Reproductive System and Pregnancy","Endometrial and Cervical Cancer Treatments","Medicine","Biology","Anastrozole","Animals","Aromatase Inhibitors","Cell Proliferation","Chick Embryo","Chorioallantoic Membrane","Disease Models, Animal","Endometriosis","Female","Humans"],"mesh_terms":["Anastrozole","Animals","Chick Embryo","Disease Models, Animal","Endometriosis","Female","Humans","Aromatase Inhibitors","Chorioallantoic Membrane","Cell Proliferation"],"keywords":["Endometriosis","Aromatase","Anastrozole","Chorioallantoic membrane","Letrozole","Aromatase inhibitor","Embryo","Estrogen","Internal medicine","Endometrium","Biology","Endocrinology","Medicine","Cancer research","Cell biology","Cancer","Chick Embryo Chorioallantoic Membrane"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.20472627.v1","title":"Additional file 2 of Lycorine inhibits angiogenesis by docking to 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