{"doi":"10.1111/jcap.70017","title":"The Impact of Adversity and Family Conflict on Risk for Future Substance Use Among Young Adolescents in the Adolescent Brain Cognitive Development Study (ABCD Study): A Cohort Analysis","abstract":"PROBLEM: 14 years old) constitutes a key target for intervention strategies. This study investigated associations between exposure to adverse childhood experiences (ACEs) and risk for future substance use among young adolescents in the United States (US); the moderating effect of family conflict was also explored. METHODS: Mixed-effects modeling was used to analyze self-report data collected from adolescents and parents at baseline and 3-year follow-up (Y3) in the Adolescent Brain Cognitive Development Study (ABCD Study) (Data Release 5.1, 2016-2022, US). FINDINGS: After adjusting for socio-demographic covariates, significant positive associations were found between adolescent ACEs score at baseline (ages 9-10) and risk for future alcohol (b = 0.03, p < 0.001), cigarette/e-cigarette (b = 0.04, p < 0.001), and marijuana use (b = 0.06, p < 0.001) at Y3 (ages 12-13) (n = 10,213 dyads). Family conflict reported at baseline was not found to moderate these associations. CONCLUSIONS: Cumulative ACEs exposure was associated with increased risk for future alcohol, cigarette/e-cigarette, and marijuana use among a national sample of young adolescents. Findings highlight the potential for trauma-informed, developmentally appropriate preventative interventions to mitigate risk for future substance use among adversity-impacted adolescents.","journal":"Journal of Child and Adolescent Psychiatric Nursing","year":2025,"id":528145,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8254,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1405534,"name":"Afsaneh Saghafi","orcid":"0000-0003-2788-3440","position":1,"is_corresponding":false},{"id":301420,"name":"Qiao Wang","orcid":"0000-0001-6416-1733","position":2,"is_corresponding":false},{"id":414372,"name":"Sanghyuk S. Shin","orcid":"0000-0001-9982-4373","position":3,"is_corresponding":false},{"id":310538,"name":"Sarahjane Dube","orcid":"0000-0002-1017-8983","position":4,"is_corresponding":false},{"id":1406164,"name":"Annabel Diestel","orcid":null,"position":5,"is_corresponding":false},{"id":486062,"name":"Robin Stevens","orcid":"0000-0002-0481-9983","position":6,"is_corresponding":false},{"id":366881,"name":"Dawn T. Bounds","orcid":"0000-0002-4116-0217","position":7,"is_corresponding":false},{"id":1161451,"name":"Sarah M. Rodrigues","orcid":"0000-0002-5514-9190","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T02:50:44.062153Z","pmid":"40265644","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}