{"doi":"10.1111/j.1749-6632.2001.tb05637.x","title":"Proteome and Proteomics for the Research on Protein Alterations in Aging","abstract":"<jats:p><jats:bold>A<jats:sc>bstract</jats:sc>: </jats:bold> Functional decline of tissues in aged animals is a result of cellular aging. Though any process of somatic cell aging basically depends on genomic instructions, phenotypes of aged cells are expressed in a given internal environment of each cell type that was made with translated proteins and post‐translationally modified products. Therefore, research on age‐dependent protein alterations in each cell type is very important in clarifying mechanisms of aging. The novel term “proteome” is a compound of “protein” and “genome,” which means constitutive whole proteins including post‐translationally modified products in a cell type. Proteomics is a novel strategy for analyzing proteomes. In proteomics, high resolution two‐dimensional electrophoresis is exclusively performed for isolation of proteins followed by mass spectrometry for identification of proteins and determination of modifications. Thus, proteomics is becoming appreciated as a powerful tool to find out proteins responsible for cellular aging, symptoms of senility and geriatric diseases.</jats:p>","journal":"Annals of the New York Academy of Sciences","year":2001,"id":23497,"datarank":0.8039314184869308,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.41918901486770027,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.41918901486770027,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":12,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":144056,"name":"Tosifusa Toda","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11795530","pmcid":null,"openalex_id":"https://openalex.org/W1999412725","authors":[],"funders":[],"total_grants":0,"fwci":1.0153,"citation_percentile":0.718923,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2020,"count":2},{"year":2022,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1749-6632.2001.tb05637.x","host_type":"publisher"},{"url":"https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.2001.tb05637.x","host_type":"publisher"},{"url":"https://doi.org/10.1111/j.1749-6632.2001.tb05637.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11795530","host_type":"repository"}],"fields_of_study":["Advanced Proteomics Techniques and Applications","Metabolomics and Mass Spectrometry Studies","Mass Spectrometry Techniques and Applications","Biology","Medicine","Aging","Algorithms","Amino Acid Motifs","Animals","Cell Fractionation","Computational Biology","Databases, Protein","Electrophoresis, Gel, Two-Dimensional","Human Genome Project","Humans","Image Processing, Computer-Assisted","Mass Spectrometry","Peptide Mapping","Protein Conformation","Protein Processing, Post-Translational","Proteome","Subtraction Technique"],"mesh_terms":["Aging","Algorithms","Animals","Cell Fractionation","Humans","Image Processing, Computer-Assisted","Peptide Mapping","Protein Conformation","Protein Processing, Post-Translational","Mass Spectrometry","Subtraction Technique","Electrophoresis, Gel, Two-Dimensional","Human Genome Project","Computational Biology","Proteome","Amino Acid Motifs","Databases, Protein"],"keywords":["Proteomics","Proteome","Computational biology","Biology","Cell","Somatic cell","Phenotype","Transcriptome","Cell biology","Two-dimensional gel electrophoresis","Cell type","Genome","Quantitative proteomics","Bioinformatics","Genetics","Gene expression","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T19:38:46.464270Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}