{"doi":"10.1111/j.1600-0854.2011.01244.x","title":"ESCRT Machinery and Cytokinesis: the Road to Daughter Cell Separation","abstract":"<jats:p><jats:bold>The endosomal sorting complex required for transport (ESCRT) machinery is a set of cellular protein complexes required for at least three topologically equivalent membrane scission events, namely multivesicular body (MVB) formation, retroviral particle release and midbody abscission during cytokinesis. Recently, several studies have explored the mechanism by which the core ESCRT‐III subunits mediate membrane scission and might be differentially required according to the functions of the pathway. In this review, we discuss the links between the ESCRT machinery and cytokinesis, with special focus on abscission initiation and regulation.</jats:bold></jats:p><jats:p><jats:inline-graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"graphic/TRA_1244_f0.gif\" xlink:title=\"inline image\"/></jats:p>","journal":"Traffic","year":2011,"id":42438,"datarank":3.8675008974938936,"base_score":4.532599493153256,"endowment":4.532599493153256,"self_citation_contribution":0.6798899239729885,"citation_network_contribution":3.187610973520905,"self_endowment_contribution":0.6798899239729885,"citer_contribution":3.187610973520905,"corpus_percentile":null,"corpus_rank":null,"citation_count":92,"citer_count":83,"citers_with_citation_signal":72,"citers_with_endowment":72,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":48.75,"fair_percentile":44.94283201407212,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":203140,"name":"Juan Martin‐Serrano","orcid":null,"position":1,"is_corresponding":false},{"id":202495,"name":"Anna Caballe","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.532599493153256,"endowment":4.532599493153256,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21722282","pmcid":null,"openalex_id":"https://openalex.org/W2067665559","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"WT093056MA","title":null},{"funder_name":"Medical Research Council","grant_id":"G0802777","title":null}],"total_grants":2,"fwci":7.1242,"citation_percentile":0.97885659,"influential_citations":6,"citation_trend":[{"year":2012,"count":25},{"year":2013,"count":14},{"year":2014,"count":9},{"year":2015,"count":7},{"year":2016,"count":4},{"year":2017,"count":3},{"year":2018,"count":5},{"year":2019,"count":2},{"year":2020,"count":4},{"year":2021,"count":5},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2024,"count":4},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0854.2011.01244.x","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0854.2011.01244.x","host_type":"publisher"},{"url":"https://doi.org/10.1111/j.1600-0854.2011.01244.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21722282","host_type":"repository"}],"fields_of_study":["Cellular transport and secretion","Lysosomal Storage Disorders Research","Calcium signaling and nucleotide metabolism","Biology","Medicine","Cytokinesis","Endosomal Sorting Complexes Required for Transport","Gene Products, gag","Humans","Protein Subunits","Protein Transport","Retroviridae","Virus Release"],"mesh_terms":["Humans","Retroviridae","Gene Products, gag","Protein Subunits","Protein Transport","Cytokinesis","Endosomal Sorting Complexes Required for Transport","Virus Release"],"keywords":["Cytokinesis","ESCRT","Midbody","Abscission","Biology","Cell biology","Endosome","Cell division","Cell","Biochemistry","Genetics","Intracellular"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-14T02:58:47.837758Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":100.0,"fair_a":70.0,"fair_i":0.0,"fair_r":25.0,"fair_zscore":0.3201,"fair_rationale":{"fair_score":48.75,"has_llm":false,"dimensions":{"F":{"name":"Findable","score":100.0,"criteria":[{"key":"f_has_doi","label":"Has a persistent DOI","kind":"deterministic","weight":1.0,"fraction":1.0,"signal":"DOI present","rationale":null},{"key":"f_repository_presence","label":"Indexed in repositories / literature DBs","kind":"deterministic","weight":1.0,"fraction":1.0,"signal":"datacite=0, pmcid=False, pmid=True","rationale":null},{"key":"f_persistent_ids","label":"Resolvable scholarly identifiers (OpenAlex)","kind":"deterministic","weight":0.5,"fraction":1.0,"signal":"OpenAlex id present","rationale":null}]},"A":{"name":"Accessible","score":70.0,"criteria":[{"key":"a_open_access","label":"Open Access / files deposited","kind":"deterministic","weight":1.5,"fraction":0.5,"signal":"files/OA location present but not flagged OA","rationale":null},{"key":"a_retrievable","label":"Free full text retrievable","kind":"deterministic","weight":1.0,"fraction":1.0,"signal":"4 OA location(s)","rationale":null}]},"I":{"name":"Interoperable","score":0.0,"criteria":[{"key":"i_linked_data","label":"Linked datasets / DataCite relations","kind":"deterministic","weight":1.0,"fraction":0.0,"signal":"linked_datasets=0, datacite=0","rationale":null},{"key":"i_standard_ids","label":"References data via standard accessions","kind":"deterministic","weight":1.0,"fraction":0.0,"signal":"accessions=0, trials=0","rationale":null}]},"R":{"name":"Reusable","score":25.0,"criteria":[{"key":"r_license","label":"Clear, open reuse license","kind":"deterministic","weight":1.5,"fraction":0.5,"signal":"license present (http://onlinelibrary.wiley.com/termsAndConditions#vor)","rationale":null},{"key":"r_downloads","label":"Demonstrated reuse (downloads)","kind":"deterministic","weight":0.5,"fraction":0.0,"signal":"downloads=0","rationale":null},{"key":"r_version","label":"Versioned / maintained","kind":"deterministic","weight":0.5,"fraction":0.0,"signal":"no version chain","rationale":null},{"key":"r_dataset","label":"Classified as a data resource","kind":"deterministic","weight":0.5,"fraction":0.0,"signal":"not a dataset","rationale":null}]}},"suggestions":["Link the underlying datasets via DOIs / DataCite relations.","Reference data using standard accessions (e.g. GEO, PDB, ClinicalTrials.gov).","Maintain explicit versioning for the dataset.","Make the paper/data Open Access or deposit the files in an open repository.","Attach a clear, open reuse license (e.g. CC-BY or CC0)."],"model":null,"agent_version":"fair_agent_v1","fulltext_source":"abstract_only"},"fair_model":null,"fair_agent_version":"fair_agent_v1","fair_fulltext_source":"abstract_only","fair_has_llm":false,"fair_computed_at":"2026-06-14T04:56:14.309857Z","clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}