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Tsg101 was sequestered along with cargo during endosomal sorting into ILVs and further degraded in lysosomes. Importantly, ESCRT‐mediated downregulation of two distinct cargoes, epidermal growth factor receptor (EGFR) and connexin43, mutually made cells refractory to degradation of the other cargo. Our observations indicate that the degradation of a key ESCRT component along with cargo represents a novel feedback control of endosomal sorting by preventing collateral degradation of cell surface receptors following stimulation of one specific pathway.</jats:bold></jats:p>","journal":"Traffic","year":2011,"id":628728,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1627971,"name":"Nina Marie Pedersen","orcid":null,"position":1,"is_corresponding":false},{"id":1627972,"name":"Catherine Elisabeth Sem Wegner","orcid":null,"position":2,"is_corresponding":false},{"id":1627973,"name":"Viola Hélène Lobert","orcid":null,"position":3,"is_corresponding":false},{"id":1627974,"name":"Edward Leithe","orcid":null,"position":4,"is_corresponding":false},{"id":568635,"name":"Andreas Brech","orcid":"0000-0002-9803-1774","position":5,"is_corresponding":false},{"id":1627975,"name":"Edgar Rivedal","orcid":null,"position":6,"is_corresponding":false},{"id":57896,"name":"Knut Liestøl","orcid":"0000-0002-7929-582X","position":7,"is_corresponding":false},{"id":201611,"name":"Harald Stenmark","orcid":null,"position":8,"is_corresponding":false},{"id":1517144,"name":"Lene Malerød","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cargo‐Dependent Degradation of ESCRT‐I as a Feedback Mechanism to Modulate Endosomal Sorting","abstract":"<jats:p><jats:bold>Ligand‐mediated lysosomal degradation of growth factor receptors, mediated by the endosomal sorting complex required for transport (ESCRT) machinery, is a mechanism that attenuates the cellular response to growth factors. 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Our observations indicate that the degradation of a key ESCRT component along with cargo represents a novel feedback control of endosomal sorting by preventing collateral degradation of cell surface receptors following stimulation of one specific pathway.</jats:bold></jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21564451","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"European Commission","grant_id":"233146","title":"The PI3K-III complex: Function in cell regulation and tumour suppression"}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":"Wiley Online Library User Agreement","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2011.01220.x","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0854.2011.01220.x","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0854.2011.01220.x","host_type":"publisher"},{"url":"https://doi.org/10.1111/j.1600-0854.2011.01220.x","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/21564451","host_type":""},{"url":"https://dx.doi.org/10.1111/j.1600-0854.2011.01220.x","host_type":""},{"url":"http://dx.doi.org/10.1111/j.1600-0854.2011.01220.x","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Cell Line","Cytoplasmic Vesicles","Endosomes","Lysosomes","Humans","Epidermal Growth Factor","DNA-Binding Proteins","Transcription Factors","RNA, Small Interfering","Culture Media, Serum-Free","Protein Transport","Feedback, Physiological","Endosomal Sorting Complexes Required for Transport","ErbB Receptors","Tsg101 Protein"],"keywords":["Feedback, Physiological","Endosomal Sorting Complexes Required for Transport","Epidermal Growth Factor","Cytoplasmic Vesicles","Endosomes","Culture Media, Serum-Free","Cell Line","DNA-Binding Proteins","ErbB Receptors","Protein Transport","Tsg101 Protein","Humans","RNA, Small Interfering","Lysosomes","Transcription Factors"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T14:48:13.542273Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}