{"doi":"10.1111/j.1600-0773.1994.tb01098.x","title":"Neuropeptide Y in Sympathetic Co‐Transmission: Recent Advances in the Search for Neuropeptide Y Antagonists","abstract":"<jats:p>Since the discovery of neuropeptide Y which is co‐stored and co‐operate with noradrenaline (NA) in sympathetic nerve fibers, several scientific groups have searched for structures with neuropeptide Y antagonistic properties. Research has mainly focused on various peptide fragments which originate from or are related to the neuropeptide Y sequence. Some non‐peptide antagonists have been proposed but they are mostly of low potency and non‐selective. Our recent observations that α‐trinositol (D‐myo‐inositol 1.2.6‐trisphosphate) is an inhibitor of neuropeptide Y effects will hopefully lead to the development of useful non‐peptide neuropeptide Y inhibitors. As a novel approach the highly selective approach of down‐regulating neuropeptide Y receptors with antisense oligodeoxynucleotides is also discussed. Neuropeptide Y antagonistic agents would help us to understand the physiological role of neuropeptide Y and may serve as useful medication in circulation disorders.</jats:p>","journal":"Pharmacology &amp; Toxicology","year":1994,"id":14969,"datarank":1.2481725662639973,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.7845161982602499,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.7845161982602499,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":12,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":115970,"name":"David Erlinge","orcid":null,"position":1,"is_corresponding":false},{"id":115971,"name":"Xiang Ying Sun","orcid":null,"position":2,"is_corresponding":false},{"id":115972,"name":"Thomas Hedner","orcid":null,"position":3,"is_corresponding":false},{"id":115969,"name":"Lars Edvinsson","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.091042453358316,"endowment":3.091042453358316,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8090686","pmcid":null,"openalex_id":"https://openalex.org/W2061285430","authors":[],"funders":[],"total_grants":0,"fwci":1.5207,"citation_percentile":0.82771614,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0773.1994.tb01098.x","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0773.1994.tb01098.x","host_type":"publisher"},{"url":"https://doi.org/10.1111/j.1600-0773.1994.tb01098.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8090686","host_type":"repository"}],"fields_of_study":["Neuropeptides and Animal Physiology","Receptor Mechanisms and Signaling","Chemical Synthesis and Analysis","Animals","Humans","Inositol Phosphates","Nerve Fibers","Neuropeptide Y","Norepinephrine","Receptors, Neuropeptide Y","Sympathetic Nervous System","Synaptic Transmission"],"mesh_terms":["Animals","Humans","Inositol Phosphates","Nerve Fibers","Synaptic Transmission","Neuropeptide Y","Norepinephrine","Sympathetic Nervous System","Receptors, Neuropeptide Y"],"keywords":["Neuropeptide Y receptor","Neuropeptide","Receptor","Peptide","Chemistry","Biology","Pharmacology","Internal medicine","Endocrinology","Medicine","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T15:49:02.595016Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}