{"doi":"10.1111/j.1600-0625.2011.01401.x","title":"Human hair follicle dermal cells and skin fibroblasts show differential activation of NF‐κB in response to pro‐inflammatory challenge","abstract":"<jats:p><jats:bold>Abstract: </jats:bold> The underlying mechanism of immune privilege in hair follicle cell dermal papilla (DP) and sheath (DS) populations is not well understood, and the responsiveness of hair follicle dermal cells to pro‐inflammatory challenge presently remains unknown. In this work, we describe acute NF‐κB activation in human DS, DP and dermal fibroblast (DF) cells challenged with TNF‐alpha and IL1‐beta. In contrast, the DS and DP cells revealed an unexpected tolerance to bacterial LPS challenge relative to DF cells. Understanding follicle cell responses to typical pro‐inflammatory stimuli is critical for diseases where collapse of hair follicle immune privilege is observed, and to further applications in autologous stem cell/wound healing therapeutics.</jats:p>","journal":"Experimental Dermatology","year":2012,"id":653810,"datarank":1.0995546639756553,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.5796942785556961,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.5796942785556961,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":26,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":200355,"name":"John W. Haycock","orcid":null,"position":1,"is_corresponding":false},{"id":1706002,"name":"Colin A. B. Jahoda","orcid":null,"position":2,"is_corresponding":false},{"id":1706001,"name":"Rebecca P. Hill","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Human hair follicle dermal cells and skin fibroblasts show differential activation of NF‐κB in response to pro‐inflammatory challenge","abstract":"<jats:p><jats:bold>Abstract: </jats:bold> The underlying mechanism of immune privilege in hair follicle cell dermal papilla (DP) and sheath (DS) populations is not well understood, and the responsiveness of hair follicle dermal cells to pro‐inflammatory challenge presently remains unknown. In this work, we describe acute NF‐κB activation in human DS, DP and dermal fibroblast (DF) cells challenged with TNF‐alpha and IL1‐beta. In contrast, the DS and DP cells revealed an unexpected tolerance to bacterial LPS challenge relative to DF cells. Understanding follicle cell responses to typical pro‐inflammatory stimuli is critical for diseases where collapse of hair follicle immune privilege is observed, and to further applications in autologous stem cell/wound healing therapeutics.</jats:p>","is_dataset_classified":null,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22141576","pmcid":null,"openalex_id":"https://openalex.org/W1506532619","authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"G1000846","title":null}],"total_grants":1,"fwci":1.2844,"citation_percentile":0.76908895,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":2},{"year":2014,"count":2},{"year":2015,"count":1},{"year":2018,"count":1},{"year":2020,"count":1},{"year":2021,"count":20},{"year":2022,"count":2},{"year":2025,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1600-0625.2011.01401.x","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-0625.2011.01401.x","host_type":"publisher"},{"url":"https://doi.org/10.1111/j.1600-0625.2011.01401.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22141576","host_type":"repository"}],"fields_of_study":["Hair Growth and Disorders","melanin and skin pigmentation","Dermatologic Treatments and Research","Active Transport, Cell Nucleus","Cells, Cultured","Dermis","Epithelial Cells","Fibroblasts","Hair Follicle","Humans","Interleukin-1beta","Lipopolysaccharides","NF-kappa B","Skin","Toll-Like Receptor 4","Transcription Factor RelA","Tumor Necrosis Factor-alpha"],"mesh_terms":["Cells, Cultured","Epithelial Cells","Fibroblasts","Humans","Lipopolysaccharides","Skin","Tumor Necrosis Factor-alpha","NF-kappa B","Hair Follicle","Dermis","Active Transport, Cell Nucleus","Toll-Like Receptor 4","Transcription Factor RelA","Interleukin-1beta"],"keywords":["Hair follicle","Immune privilege","Cell biology","Immune system","Dermal fibroblast","Dermis","Dermal papillae","Inflammation","Immunology","Biology","Wound healing","Fibroblast","Cell culture","Anatomy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T01:03:09.753434Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}