{"doi":"10.1111/j.1468-1293.2012.01012.x","title":"Factors associated with a strictly undetectable viral load in HIV‐1‐infected patients","abstract":"ObjectivesThe aim of the study was to identify factors associated with a strictly undetectable viral load (VL) using a routine sensitive real‐time polymerase chain reaction (RT‐PCR) technology.MethodsFrom a large prospective cohort, 1392 patients with a VL < 50 HIV‐1 RNA copies/mL while receiving a three‐drug suppressive regimen for at least 1 year were included in a cross‐sectional analysis. Patients were classified into three groups and compared by univariate and multivariate analysis: 479 patients with a strictly undetectable VL (group 1; 34%), 617 patients with detectable VL below the threshold of 20 copies/mL (group 2; 44%), and 296 patients with a VL of 20–50 copies/mL (group 3; 12%).ResultsComparing groups 1 and 2, VL zenith < 5 log10 copies/mL [odds ratio (OR) 1.51; 95% confidence interval (CI) 1.15–1.99; P = 0.003], current CD4 T‐cell count < 500 cells/μL (OR 1.44; 95% CI 1.08–1.92; P = 0.01), and duration of viral suppression < 50 copies/mL longer than 2 years (OR 2.32; 95% CI 1.20–4.54; P = 0.01) were associated with undetectable VL. Comparing groups 1 and 3, VL zenith < 5 log10 copies/mL (OR 2.48; 95% CI 1.75–3.50; P < 0.001), duration of viral suppression < 50 copies/mL longer than 1 year (OR 3.33; 95% CI 1.66–6.66; P = 0.0006), and nonnucleoside reverse transcriptase inhibitor (NNRTI)‐based regimens (OR 1.45; 95% CI 1.03–2.04; P = 0.03) were associated with undetectable VL. No individual drug effect was found within NNRTI molecules.ConclusionsLonger duration of viral suppression < 50 copies/mL, lower viral load zenith and NNRTI‐based regimen were independently associated with a strictly undetectable viral load. This routinely used RT‐PCR assay may prove to be a valuable tool in further large‐scale studies.","journal":"HIV Medicine","year":2012,"id":628645,"datarank":0.4636563680037475,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.0,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1627699,"name":"K Sauné","orcid":null,"position":1,"is_corresponding":false},{"id":1627700,"name":"V Vu Hai","orcid":null,"position":2,"is_corresponding":false},{"id":1627701,"name":"B Marchou","orcid":null,"position":3,"is_corresponding":false},{"id":1623350,"name":"P Delobel","orcid":null,"position":4,"is_corresponding":false},{"id":1627702,"name":"J Izopet","orcid":null,"position":5,"is_corresponding":false},{"id":1623150,"name":"L Cuzin","orcid":null,"position":6,"is_corresponding":false},{"id":1627703,"name":"P Massip","orcid":null,"position":7,"is_corresponding":false},{"id":1627698,"name":"G Martin‐Blondel","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Factors associated with a strictly undetectable viral load in HIV‐1‐infected patients","abstract":"ObjectivesThe aim of the study was to identify factors associated with a strictly undetectable viral load (VL) using a routine sensitive real‐time polymerase chain reaction (RT‐PCR) technology.MethodsFrom a large prospective cohort, 1392 patients with a VL < 50 HIV‐1 RNA copies/mL while receiving a three‐drug suppressive regimen for at least 1 year were included in a cross‐sectional analysis. Patients were classified into three groups and compared by univariate and multivariate analysis: 479 patients with a strictly undetectable VL (group 1; 34%), 617 patients with detectable VL below the threshold of 20 copies/mL (group 2; 44%), and 296 patients with a VL of 20–50 copies/mL (group 3; 12%).ResultsComparing groups 1 and 2, VL zenith < 5 log10 copies/mL [odds ratio (OR) 1.51; 95% confidence interval (CI) 1.15–1.99; P = 0.003], current CD4 T‐cell count < 500 cells/μL (OR 1.44; 95% CI 1.08–1.92; P = 0.01), and duration of viral suppression < 50 copies/mL longer than 2 years (OR 2.32; 95% CI 1.20–4.54; P = 0.01) were associated with undetectable VL. Comparing groups 1 and 3, VL zenith < 5 log10 copies/mL (OR 2.48; 95% CI 1.75–3.50; P < 0.001), duration of viral suppression < 50 copies/mL longer than 1 year (OR 3.33; 95% CI 1.66–6.66; P = 0.0006), and nonnucleoside reverse transcriptase inhibitor (NNRTI)‐based regimens (OR 1.45; 95% CI 1.03–2.04; P = 0.03) were associated with undetectable VL. No individual drug effect was found within NNRTI molecules.ConclusionsLonger duration of viral suppression < 50 copies/mL, lower viral load zenith and NNRTI‐based regimen were independently associated with a strictly undetectable viral load. This routinely used RT‐PCR assay may prove to be a valuable tool in further large‐scale studies.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22435457","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1468-1293.2012.01012.x","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1468-1293.2012.01012.x","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Humans","HIV-1","HIV Seropositivity","Anti-HIV Agents","CD4 Lymphocyte Count","Drug Therapy, Combination","Viral Load","Risk Factors","Prospective Studies","Cross-Sectional Studies","Female","Male","Real-Time Polymerase Chain Reaction"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T14:25:57.844304Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}