{"doi":"10.1111/j.1462-5822.2006.00697.x","title":"Expression of human CD81 differently affects host cell susceptibility to malaria sporozoites depending on the Plasmodium species","abstract":null,"journal":"Cellular Microbiology","year":2006,"id":47210,"datarank":3.54719951394385,"base_score":4.74493212836325,"endowment":4.74493212836325,"self_citation_contribution":0.7117398192544876,"citation_network_contribution":2.8354596946893627,"self_endowment_contribution":0.7117398192544876,"citer_contribution":2.8354596946893627,"corpus_percentile":null,"corpus_rank":null,"citation_count":114,"citer_count":74,"citers_with_citation_signal":64,"citers_with_endowment":64,"datacite_reuse_total":16,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":217824,"name":"Celine Greco","orcid":null,"position":1,"is_corresponding":false},{"id":217825,"name":"Jean-Francois Franetich","orcid":null,"position":2,"is_corresponding":false},{"id":217826,"name":"Anne Dubart-Kupperschmitt","orcid":null,"position":3,"is_corresponding":false},{"id":148948,"name":"Laurent Hannoun","orcid":null,"position":4,"is_corresponding":false},{"id":217827,"name":"Geert-Jan van Gemert","orcid":null,"position":5,"is_corresponding":false},{"id":217828,"name":"Robert W. 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We now provide evidence that following invasion without PV formation, transmigrating Plasmodium falciparum and Plasmodium yoelii sporozoites can partially develop into EEFs inside hepatocarcinoma cell nuclei. We also found that rodent P. yoelii sporozoites can infect both mouse and human hepatocytes, while human P. falciparum sporozoites infect human but not mouse hepatocytes. We have previously reported that the host tetraspanin CD81 is required for PV formation by P. falciparum and P. yoelii sporozoites. Here we show that expression of human CD81 in CD81-knockout mouse hepatocytes is sufficient to confer susceptibility to P. yoelii but not P. falciparum sporozoite infection, showing that the narrow P. falciparum host tropism does not rely on CD81 only. Also, expression of CD81 in a human hepatocarcinoma cell line is sufficient to promote the formation of a PV by P. yoelii but not P. falciparum sporozoites. These results highlight critical differences between P. yoelii and P. falciparum sporozoite infection, and suggest that in addition to CD81, other molecules are specifically required for PV formation during infection by the human malaria parasite.","is_dataset_classified":null,"base_score":4.74493212836325,"endowment":4.74493212836325,"datacite_reuse_total":16,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16819966","pmcid":null,"openalex_id":"https://openalex.org/W2093867776","authors":[],"funders":[{"funder_name":"NIAID NIH 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Research and Control","Drug Transport and Resistance Mechanisms","Hepatitis B Virus Studies","Biology","Medicine","Animals","Animals, Genetically Modified","Antigens, CD","Cell Line, Tumor","Cell Nucleus","Host-Parasite Interactions","Humans","Mice","Plasmodium falciparum","Plasmodium yoelii","Species Specificity","Sporozoites","Tetraspanin 28"],"mesh_terms":["Animals","Cell Nucleus","Host-Parasite Interactions","Humans","Plasmodium falciparum","Plasmodium yoelii","Species Specificity","Antigens, CD","Animals, Genetically Modified","Sporozoites","Cell Line, Tumor","Mice","Tetraspanin 28"],"keywords":["Plasmodium yoelii","CD81","Biology","Plasmodium falciparum","Virology","Tetraspanin","Plasmodium (life cycle)","Malaria","Apicomplexa","Parasite hosting","Cell biology","Immunology","Cell","Virus","Genetics","Parasitemia"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.11998872.v1","title":"Additional file 1 of 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