{"doi":"10.1111/j.1440-1827.2007.02119.x","title":"Missense mutation with/without nonsense mutation of the <i>p53 </i>gene is associated with large cell morphology in human malignant lymphoma","abstract":"<jats:p>Mutations in <jats:italic>p53</jats:italic> gene exons 5–9 were studied in 44 non‐Hodgkin's lymphomas (NHL) consisting of 35 B‐NHL and 9 T‐NHL. Missense mutations were found in two diffuse large B‐cell lymphomas (DLBL) and one peripheral T‐cell lymphoma (unspecified). Double transversion missense and nonsense mutations were detected in one DLBL and one adult T‐cell leukemia/lymphoma. Silent mutations were found in two DLBL. Detailed histomorphological study showed that cases harboring <jats:italic>p53</jats:italic> missense mutation with/without nonsense mutation tended to have larger nuclei with much more prominent nucleoli. Cytomorphometric analysis was therefore conducted by measuring the gross area of 100 lymphoma cell nuclei in 44 cases and the results were compared between lymphomas harboring <jats:italic>p53</jats:italic> missense mutation with/without nonsense mutation and lymphomas harboring <jats:italic>p53</jats:italic> silent mutation or lacking mutation. It was found that the lymphomas harboring <jats:italic>p53</jats:italic> missense mutation with/without nonsense mutation had a highly significantly larger nuclear gross area than lymphomas with silent <jats:italic>p53</jats:italic> mutation or lacking mutation (two‐sample <jats:italic>t</jats:italic>‐test, <jats:italic>P</jats:italic> &lt; 0.00001; Exact Wilcoxon rank–sum test, <jats:italic>P</jats:italic> &lt; 0.00001). This result suggests that <jats:italic>p53</jats:italic> mutation might induce enlargement of neoplastic cell nuclei by some molecular mechanism.</jats:p>","journal":"Pathology International","year":2007,"id":626572,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":133329,"name":"Hiroshi Kamata","orcid":null,"position":1,"is_corresponding":false},{"id":1620830,"name":"Mutsunori Fujiwara","orcid":null,"position":2,"is_corresponding":false},{"id":1620833,"name":"Naoto Aoki","orcid":null,"position":3,"is_corresponding":false},{"id":1620835,"name":"Shuji Okada","orcid":null,"position":4,"is_corresponding":false},{"id":1620837,"name":"Masato Watanabe","orcid":null,"position":5,"is_corresponding":false},{"id":1620839,"name":"Toshiro Tango","orcid":null,"position":6,"is_corresponding":false},{"id":1620841,"name":"Shigero Mori","orcid":null,"position":7,"is_corresponding":false},{"id":1620826,"name":"Shoko Mitani","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Missense mutation with/without nonsense mutation of the <i>p53 </i>gene is associated with large cell morphology in human malignant lymphoma","abstract":"<jats:p>Mutations in <jats:italic>p53</jats:italic> gene exons 5–9 were studied in 44 non‐Hodgkin's lymphomas (NHL) consisting of 35 B‐NHL and 9 T‐NHL. Missense mutations were found in two diffuse large B‐cell lymphomas (DLBL) and one peripheral T‐cell lymphoma (unspecified). Double transversion missense and nonsense mutations were detected in one DLBL and one adult T‐cell leukemia/lymphoma. Silent mutations were found in two DLBL. Detailed histomorphological study showed that cases harboring <jats:italic>p53</jats:italic> missense mutation with/without nonsense mutation tended to have larger nuclei with much more prominent nucleoli. Cytomorphometric analysis was therefore conducted by measuring the gross area of 100 lymphoma cell nuclei in 44 cases and the results were compared between lymphomas harboring <jats:italic>p53</jats:italic> missense mutation with/without nonsense mutation and lymphomas harboring <jats:italic>p53</jats:italic> silent mutation or lacking mutation. It was found that the lymphomas harboring <jats:italic>p53</jats:italic> missense mutation with/without nonsense mutation had a highly significantly larger nuclear gross area than lymphomas with silent <jats:italic>p53</jats:italic> mutation or lacking mutation (two‐sample <jats:italic>t</jats:italic>‐test, <jats:italic>P</jats:italic> &lt; 0.00001; Exact Wilcoxon rank–sum test, <jats:italic>P</jats:italic> &lt; 0.00001). This result suggests that <jats:italic>p53</jats:italic> mutation might induce enlargement of neoplastic cell nuclei by some molecular mechanism.</jats:p>","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17587242","pmcid":null,"openalex_id":"https://openalex.org/W1974547943","authors":[],"funders":[],"total_grants":0,"fwci":0.143,"citation_percentile":0.50422346,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2021,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1440-1827.2007.02119.x","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1440-1827.2007.02119.x","host_type":"publisher"},{"url":"https://doi.org/10.1111/j.1440-1827.2007.02119.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17587242","host_type":"repository"}],"fields_of_study":["Cancer-related Molecular Pathways","T-cell and Retrovirus Studies","Lymphoma Diagnosis and Treatment"],"mesh_terms":["Adult","Aged","Aged, 80 and over","Cell Nucleus","DNA Mutational Analysis","DNA, Neoplasm","Female","Humans","Male","Middle Aged","Genes, p53","Lymphoma, Large B-Cell, Diffuse","Codon, Nonsense","Mutation, Missense"],"keywords":["Missense mutation","Nonsense mutation","Lymphoma","Nonsense","Mutation","Biology","Cancer research","Non-Hodgkin's lymphoma","T-cell lymphoma","Molecular biology","Genetics","Pathology","Gene","Medicine","Immunology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T14:22:20.873653Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}