{"doi":"10.1111/j.1399-0012.2011.01588.x","title":"Pulmonary hypertension before first and second lung transplantation","abstract":"<jats:p>Tonelli AR, Timofte I, Minai OA, Baz M, Akindipe O. Pulmonary hypertension before first and second lung transplantation.</jats:p><jats:p><jats:bold>Abstract: </jats:bold><jats:bold> Background: </jats:bold> Pulmonary hypertension (PH) is frequently encountered in patients with advanced lung disease before the first and second lung transplantation. We sought to determine whether there is any relationship between pulmonary hemodynamics obtained before first and second lung transplantation. We also assessed whether PH has prognostic implications in lung transplant patients going for second transplantation.</jats:p><jats:p><jats:bold>Methods: </jats:bold> We included consecutive adult (16‐yr‐old or older) patients who underwent lung re‐transplantation, between 1997 and 2009, and had right heart catheterization before their first and second lung transplantation.</jats:p><jats:p><jats:bold>Results: </jats:bold> Eighteen patients were included in the study. Age at first transplantation was 50.4 (SD 10.4) yr, and bronchiolitis obliterans syndrome (BOS) in the transplanted lung was the only indication for re‐transplantation. PH was observed in 39% of the patients before the first lung transplant and in 56% of the subjects before re‐transplantation (p = 0.91). Pre‐capillary PH was present in 28% (n = 5) and 33% (n = 6) of the patients before first and second lung transplantation, respectively. None of the hemodynamic variables obtained before the first transplant predicted the development of PH before re‐transplantation. PH before re‐transplantation did not predict survival or development of BOS after re‐transplantation.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> PH before initial lung transplantation did not predict the development of PH before the second transplantation. In our cohort, PH before second lung transplantation did not predict outcomes after re‐transplantation.</jats:p>","journal":"Clinical Transplantation","year":2012,"id":593242,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1518371,"name":"Irina Timofte","orcid":null,"position":1,"is_corresponding":false},{"id":1518372,"name":"Omar A. Minai","orcid":null,"position":2,"is_corresponding":false},{"id":1518373,"name":"Maher Baz","orcid":null,"position":3,"is_corresponding":false},{"id":1518374,"name":"Olufemi Akindipe","orcid":null,"position":4,"is_corresponding":false},{"id":55479,"name":"Adriano R. Tonelli","orcid":"0000-0002-2321-9545","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Pulmonary hypertension before first and second lung transplantation","abstract":"<jats:p>Tonelli AR, Timofte I, Minai OA, Baz M, Akindipe O. Pulmonary hypertension before first and second lung transplantation.</jats:p><jats:p><jats:bold>Abstract: </jats:bold><jats:bold> Background: </jats:bold> Pulmonary hypertension (PH) is frequently encountered in patients with advanced lung disease before the first and second lung transplantation. We sought to determine whether there is any relationship between pulmonary hemodynamics obtained before first and second lung transplantation. We also assessed whether PH has prognostic implications in lung transplant patients going for second transplantation.</jats:p><jats:p><jats:bold>Methods: </jats:bold> We included consecutive adult (16‐yr‐old or older) patients who underwent lung re‐transplantation, between 1997 and 2009, and had right heart catheterization before their first and second lung transplantation.</jats:p><jats:p><jats:bold>Results: </jats:bold> Eighteen patients were included in the study. Age at first transplantation was 50.4 (SD 10.4) yr, and bronchiolitis obliterans syndrome (BOS) in the transplanted lung was the only indication for re‐transplantation. PH was observed in 39% of the patients before the first lung transplant and in 56% of the subjects before re‐transplantation (p = 0.91). Pre‐capillary PH was present in 28% (n = 5) and 33% (n = 6) of the patients before first and second lung transplantation, respectively. None of the hemodynamic variables obtained before the first transplant predicted the development of PH before re‐transplantation. PH before re‐transplantation did not predict survival or development of BOS after re‐transplantation.</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> PH before initial lung transplantation did not predict the development of PH before the second transplantation. In our cohort, PH before second lung transplantation did not predict outcomes after re‐transplantation.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22320224","pmcid":"PMC3368041","openalex_id":"https://openalex.org/W1524112221","authors":[],"funders":[{"funder_name":"NCATS NIH HHS","grant_id":"UL1 TR000064","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"KL2 RR024990","title":null}],"total_grants":2,"fwci":0.0,"citation_percentile":0.04292073,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://europepmc.org/articles/pmc3368041?pdf=render","host_type":"GREEN"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1399-0012.2011.01588.x","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0012.2011.01588.x","host_type":"publisher"},{"url":"https://doi.org/10.1111/j.1399-0012.2011.01588.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22320224","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3368041","host_type":"repository"}],"fields_of_study":["Transplantation: Methods and Outcomes","Pulmonary Hypertension Research and Treatments","Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","Medicine"],"mesh_terms":["Adolescent","Adult","Bronchiolitis Obliterans","Female","Follow-Up Studies","Cardiac Catheterization","Humans","Hypertension, Pulmonary","Male","Middle Aged","Postoperative Complications","Prognosis","Reoperation","Lung Transplantation","Young Adult"],"keywords":["Lung transplantation","Transplantation","Bronchiolitis obliterans","Medicine","Pulmonary hypertension","Lung","Internal medicine","Surgery"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T17:57:12.131373Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}