{"doi":"10.1111/j.1398-9995.2007.01568.x","title":"Short communication: Lupin allergy in peanut‐allergic children and teenagers","abstract":"<jats:p><jats:bold>Background: </jats:bold> Lupin has now been introduced into food production in the UK. There is a concern that, on account of cross‐reactivity, peanut‐allergic children are at high risk for lupin allergy.</jats:p><jats:p><jats:bold>Aims: </jats:bold> To investigate the prevalence of lupin sensitization and allergy in children with peanut allergy compared with atopic controls.</jats:p><jats:p><jats:bold>Methods: </jats:bold> Children (&lt;18 years) were recruited. Peanut‐allergic subjects either had a convincing history of peanut allergy with diagnostic peanut skin prick test (SPT) or specific‐immunoglobulin E (IgE) results or a positive food challenge. Control subjects were atopic but not peanut‐allergic. All subjects had SPT to peanut and lupin. Sensitized subjects were offered a randomized, double‐blind, placebo‐controlled lupin challenge. Lupin allergy was defined as objective immediate hypersensitivity reaction at food challenge.</jats:p><jats:p><jats:bold>Results: </jats:bold> Forty‐seven peanut‐allergic children and 46 atopic controls were recruited. Sixteen peanut‐allergic children were sensitized to lupin [34%, 95% confidence interval (CI): 21–49%]. Nine were challenged to lupin. Two reacted (itchy mouth and urticaria; itchy mouth and 20% drop in peak expiratory flow rate) giving a minimum prevalence of lupin allergy in peanut‐allergic children of 4.0% (95% CI: 1–15%). Atopic controls were significantly (<jats:italic>P</jats:italic> = 0.001) less likely to be sensitized to lupin (4%, 95% CI: 1–15%) and had smaller wheals and serum‐specific IgE results. None of the atopic controls reacted on lupin challenge, giving a rate of allergy in the atopic controls of 0% (95% CI: 0–8%).</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> A small but significant number of children with peanut allergy are allergic to lupin. Sensitization to lupin is much rarer in nonpeanut‐allergic atopic subjects.</jats:p>","journal":"Allergy","year":2008,"id":645035,"datarank":0.6515708132780527,"base_score":4.343805421853684,"endowment":4.343805421853684,"self_citation_contribution":0.6515708132780527,"citation_network_contribution":0.0,"self_endowment_contribution":0.6515708132780527,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":76,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1679352,"name":"G. Roberts","orcid":null,"position":1,"is_corresponding":false},{"id":1679353,"name":"K. Grimshaw","orcid":null,"position":2,"is_corresponding":false},{"id":187910,"name":"S. White","orcid":null,"position":3,"is_corresponding":false},{"id":1679354,"name":"J. Hourihane","orcid":null,"position":4,"is_corresponding":false},{"id":1371151,"name":"J. Shaw","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Short communication: Lupin allergy in peanut‐allergic children and teenagers","abstract":"<jats:p><jats:bold>Background: </jats:bold> Lupin has now been introduced into food production in the UK. There is a concern that, on account of cross‐reactivity, peanut‐allergic children are at high risk for lupin allergy.</jats:p><jats:p><jats:bold>Aims: </jats:bold> To investigate the prevalence of lupin sensitization and allergy in children with peanut allergy compared with atopic controls.</jats:p><jats:p><jats:bold>Methods: </jats:bold> Children (&lt;18 years) were recruited. Peanut‐allergic subjects either had a convincing history of peanut allergy with diagnostic peanut skin prick test (SPT) or specific‐immunoglobulin E (IgE) results or a positive food challenge. Control subjects were atopic but not peanut‐allergic. All subjects had SPT to peanut and lupin. Sensitized subjects were offered a randomized, double‐blind, placebo‐controlled lupin challenge. Lupin allergy was defined as objective immediate hypersensitivity reaction at food challenge.</jats:p><jats:p><jats:bold>Results: </jats:bold> Forty‐seven peanut‐allergic children and 46 atopic controls were recruited. Sixteen peanut‐allergic children were sensitized to lupin [34%, 95% confidence interval (CI): 21–49%]. Nine were challenged to lupin. Two reacted (itchy mouth and urticaria; itchy mouth and 20% drop in peak expiratory flow rate) giving a minimum prevalence of lupin allergy in peanut‐allergic children of 4.0% (95% CI: 1–15%). Atopic controls were significantly (<jats:italic>P</jats:italic> = 0.001) less likely to be sensitized to lupin (4%, 95% CI: 1–15%) and had smaller wheals and serum‐specific IgE results. None of the atopic controls reacted on lupin challenge, giving a rate of allergy in the atopic controls of 0% (95% CI: 0–8%).</jats:p><jats:p><jats:bold>Conclusions: </jats:bold> A small but significant number of children with peanut allergy are allergic to lupin. Sensitization to lupin is much rarer in nonpeanut‐allergic atopic subjects.</jats:p>","is_dataset_classified":null,"base_score":4.343805421853684,"endowment":4.343805421853684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18028245","pmcid":null,"openalex_id":"https://openalex.org/W1521380121","authors":[],"funders":[],"total_grants":0,"fwci":3.9276,"citation_percentile":0.93770919,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":6},{"year":2014,"count":4},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2018,"count":6},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":5},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":5},{"year":2025,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1398-9995.2007.01568.x","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1398-9995.2007.01568.x","host_type":"publisher"},{"url":"https://doi.org/10.1111/j.1398-9995.2007.01568.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18028245","host_type":"repository"},{"url":"https://eprints.soton.ac.uk/61509/","host_type":"repository"}],"fields_of_study":["Food Allergy and Anaphylaxis Research","Botanical Research and Chemistry","Asthma and respiratory diseases"],"mesh_terms":["Adolescent","Allergens","Child","Child, Preschool","Double-Blind Method","Female","Food Hypersensitivity","United Kingdom","Humans","Immunoglobulin E","Immunization","Male","Probability","Reference Values","Sensitivity and Specificity","Skin Tests","Confidence Intervals","Risk Assessment","Peanut Hypersensitivity","Lupinus"],"keywords":["Peanut allergy","Allergy","Medicine","Food allergy","Oral allergy syndrome","Immunoglobulin E","Sensitization","Atopy","Atopic dermatitis","Immunology","Milk allergy","Confidence interval","Asthma","Arachis","Internal medicine","Biology","Antibody","Agronomy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T02:39:36.824120Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}