{"doi":"10.1111/j.1365-313x.2012.05051.x","title":"<i>De novo</i>\n                    DNA methylation activity of METHYLTRANSFERASE 1 (MET1) partially restores body methylation in\n                    <i>Arabidopsis thaliana</i>","abstract":"<jats:title>Summary</jats:title>\n                  <jats:p>\n                    Arabidopsis METHYLTRANSFERASE 1 (MET1) controls faithful maintenance of cytosine methylation at CG sites in repetitive regions and central body regions of active genes. If MET1 is removed in a mutant background, CG methylation is lost and is only restored in specific heterochromatic regions that have maintained competence for re‐methylation due to the presence of small RNAs and the RNA‐directed DNA methylation pathway that controls\n                    <jats:italic>de novo</jats:italic>\n                    DNA methylation functions. We analysed re‐methylation at a locus that loses body methylation in an\n                    <jats:italic>met1</jats:italic>\n                    mutant. We found that body methylation at this locus is at least partially restored when MET1 is re‐introduced into the\n                    <jats:italic>met1</jats:italic>\n                    mutant background, either via genetic cross or DNA transfer. Re‐methylation is region‐specific but random with respect to individual CG targets, does not require passage through the germline, and its efficiency appears to be influenced by transcription. This suggests that, at least at some loci, MET1 has\n                    <jats:italic>de novo</jats:italic>\n                    methylation activity that can restore lost body methylation patterns. We propose that this activity helps to stabilize body methylation patterns, and the random target site selection probably also enhances the variability of body methylation patterns.\n                  </jats:p>","journal":"The Plant 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Molecular Biology Research","Plant nutrient uptake and metabolism","Plant responses to water stress","Biology","Medicine","Environmental Science","Arabidopsis","Arabidopsis Proteins","DNA (Cytosine-5-)-Methyltransferases","DNA Methylation","DNA, Complementary","DNA, Plant","Gene Expression Regulation, Plant","Mutagenesis, Insertional","Plant Roots","Plants, Genetically Modified","RNA, Plant"],"mesh_terms":["DNA (Cytosine-5-)-Methyltransferases","Mutagenesis, Insertional","Arabidopsis","DNA, Complementary","Gene Expression Regulation, Plant","Plant Roots","DNA, Plant","RNA, Plant","DNA Methylation","Arabidopsis Proteins","Plants, Genetically Modified"],"keywords":["Methylation","RNA-Directed DNA Methylation","Epigenetics of physical exercise","DNA methylation","Biology","Methyltransferase","Genetics","Illumina Methylation Assay","Epigenomics","Histone methylation","CpG site","Molecular biology","DNA","Gene","Gene 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