{"doi":"10.1111/j.1365-313x.2011.04825.x","title":"The chloroplast division mutant <i>caa33</i> of <i>Arabidopsis thaliana</i> reveals the crucial impact of chloroplast homeostasis on stress acclimation and retrograde plastid‐to‐nucleus signaling","abstract":"<jats:title>Summary</jats:title><jats:p>Retrograde plastid‐to‐nucleus signaling tightly controls and coordinates the nuclear and plastid gene expression that is required for plastid biogenesis and chloroplast activity. As chloroplasts act as sensors of environmental changes, plastid‐derived signaling also modulates stress responses of plants by transferring stress‐related signals and altering nuclear gene expression. Various mutant screens have been undertaken to identify constituents of plastid signaling pathways. Almost all mutations identified in these screens target plastid‐specific but not extraplastidic functions. They have been suggested to define either genuine constituents of retrograde signaling pathways or components required for the synthesis of plastid signals. Here we report the characterization of the <jats:italic>constitutive activator of AAA‐ATPase</jats:italic> (<jats:italic>caa33</jats:italic>) mutant, which reveals another way of how mutations that affect plastid functions may modulate retrograde plastid signaling. <jats:italic>caa33</jats:italic> disturbs a plastid‐specific function by impeding plastid division, and thereby perturbing plastid homeostasis. This results in preconditioning plants by activating the expression of stress genes, enhancing pathogen resistance and attenuating the capacity of the plant to respond to plastid signals. Our study reveals an intimate link between chloroplast activity and the susceptibility of the plant to stress, and emphasizes the need to consider the possible impact of preconditioning on retrograde plastid‐to‐nucleus signaling.</jats:p>","journal":"The Plant Journal","year":2012,"id":656367,"datarank":0.5333022092234121,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"self_citation_contribution":0.5333022092234121,"citation_network_contribution":0.0,"self_endowment_contribution":0.5333022092234121,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1713403,"name":"Chanhong Kim","orcid":null,"position":1,"is_corresponding":false},{"id":1713404,"name":"Katarzyna Gacek","orcid":null,"position":2,"is_corresponding":false},{"id":585585,"name":"Aiswarya Baruah","orcid":"0000-0003-2987-8143","position":3,"is_corresponding":false},{"id":1713405,"name":"Christophe Laloi","orcid":null,"position":4,"is_corresponding":false},{"id":346252,"name":"Klaus Apel","orcid":null,"position":5,"is_corresponding":false},{"id":1713402,"name":"Klára Šimková","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The chloroplast division mutant <i>caa33</i> of <i>Arabidopsis thaliana</i> reveals the crucial impact of chloroplast homeostasis on stress acclimation and retrograde plastid‐to‐nucleus signaling","abstract":"<jats:title>Summary</jats:title><jats:p>Retrograde plastid‐to‐nucleus signaling tightly controls and coordinates the nuclear and plastid gene expression that is required for plastid biogenesis and chloroplast activity. As chloroplasts act as sensors of environmental changes, plastid‐derived signaling also modulates stress responses of plants by transferring stress‐related signals and altering nuclear gene expression. Various mutant screens have been undertaken to identify constituents of plastid signaling pathways. Almost all mutations identified in these screens target plastid‐specific but not extraplastidic functions. They have been suggested to define either genuine constituents of retrograde signaling pathways or components required for the synthesis of plastid signals. Here we report the characterization of the <jats:italic>constitutive activator of AAA‐ATPase</jats:italic> (<jats:italic>caa33</jats:italic>) mutant, which reveals another way of how mutations that affect plastid functions may modulate retrograde plastid signaling. <jats:italic>caa33</jats:italic> disturbs a plastid‐specific function by impeding plastid division, and thereby perturbing plastid homeostasis. This results in preconditioning plants by activating the expression of stress genes, enhancing pathogen resistance and attenuating the capacity of the plant to respond to plastid signals. Our study reveals an intimate link between chloroplast activity and the susceptibility of the plant to stress, and emphasizes the need to consider the possible impact of preconditioning on retrograde plastid‐to‐nucleus signaling.</jats:p>","is_dataset_classified":null,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22014227","pmcid":"PMC3274639","openalex_id":"https://openalex.org/W2144426765","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM085036","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01-GM085036","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R01GM085036-01A2","title":"The genetic basis of singlet oxygen-mediated signaling in eukaryotic cells"}],"total_grants":3,"fwci":1.702,"citation_percentile":0.84166002,"influential_citations":1,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":6},{"year":2014,"count":3},{"year":2015,"count":2},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2018,"count":2},{"year":2020,"count":3},{"year":2021,"count":1},{"year":2022,"count":3},{"year":2023,"count":2},{"year":2024,"count":2},{"year":2025,"count":2}],"oa_status":"green","license":"Wiley Online Library User Agreement","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3274639","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc3274639?pdf=render","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3274639","host_type":"repository"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-313X.2011.04825.x","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-313X.2011.04825.x","host_type":"publisher"},{"url":"https://doi.org/10.1111/j.1365-313x.2011.04825.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22014227","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3274639","host_type":"repository"},{"url":"https://hal.science/hal-03034813","host_type":"repository"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-313X.2011.04825.x","host_type":""},{"url":"https://dx.doi.org/10.1111/j.1365-313x.2011.04825.x","host_type":""},{"url":"https://sonar.ch/global/documents/253643","host_type":""},{"url":"https://hal.science/hal-03034813v1","host_type":""},{"url":"https://hal.science/hal-03034813v1/document","host_type":""}],"fields_of_study":["Photosynthetic Processes and Mechanisms","Plant responses to water stress","Plant Stress Responses and Tolerance","Biology","Medicine","Environmental Science","0301 basic medicine","0303 health sciences","03 medical and health sciences","Acclimatization","Adenosine Triphosphatases","Adenosine Triphosphate","Alleles","Arabidopsis","Arabidopsis Proteins","Cell Death","Cell Nucleus","Chloroplasts","Gene Expression Regulation, Plant","Homeostasis","Light","Mesophyll Cells","Mutation","Phenotype","Signal Transduction","Singlet Oxygen","Stress, Physiological"],"mesh_terms":["Acclimatization","Adenosine Triphosphatases","Adenosine Triphosphate","Alleles","Cell Nucleus","Chloroplasts","Homeostasis","Light","Mutation","Phenotype","Stress, Physiological","Signal Transduction","Cell Death","Arabidopsis","Gene Expression Regulation, Plant","Singlet Oxygen","Arabidopsis Proteins","Mesophyll Cells"],"keywords":["Plastid","Retrograde signaling","Biology","Chloroplast","Arabidopsis thaliana","Cell biology","Arabidopsis","Mutant","Biogenesis","Nuclear gene","Genetics","Signal transduction","Gene","Genome","Adenosine Triphosphatases","Cell Nucleus","Chloroplasts","Cell Death","Light","Singlet Oxygen","Arabidopsis Proteins","Acclimatization","[SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology","Adenosine Triphosphate","Phenotype","Gene Expression Regulation, Plant","Stress, Physiological","Mutation","[SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]","Homeostasis","[SDV.BV.AP] Life Sciences [q-bio]/Vegetal Biology/Plant breeding","Mesophyll Cells","Alleles"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T20:39:59.478592Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}