{"doi":"10.1111/j.1365-2559.2004.01766.x","title":"Applications of microarrays to histopathology","abstract":"<jats:p>High‐throughput microarray technologies have the potential to impact significantly on the practice of histopathology over the coming years. Global gene expression profiling allows for a systematic search of all human genes for novel diagnostic and prognostic markers and for potential therapeutic targets. Likewise, gene copy number changes can be determined on a gene‐by‐gene basis using microarrays. Tissue microarrays are an efficient method to extend and validate the findings obtained from the initial ‘discovery’ phase of the research, done using cDNA microarrays. In addition, tissue microarrays can be used for quality assurance for immunohistochemical and <jats:italic>in situ</jats:italic> hybridization procedures. In this review we give a brief overview of microarray technology and research uses, and discuss potential applications of microarrays in the practice of diagnostic histopathology.</jats:p>","journal":"Histopathology","year":2004,"id":14300,"datarank":5.81404322585683,"base_score":4.634728988229636,"endowment":4.634728988229636,"self_citation_contribution":0.6952093482344455,"citation_network_contribution":5.118833877622384,"self_endowment_contribution":0.6952093482344455,"citer_contribution":5.118833877622384,"corpus_percentile":null,"corpus_rank":null,"citation_count":102,"citer_count":99,"citers_with_citation_signal":77,"citers_with_endowment":77,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":113619,"name":"C B Gilks","orcid":null,"position":1,"is_corresponding":false},{"id":113618,"name":"M Van De Rijn","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.634728988229636,"endowment":4.634728988229636,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"14764053","pmcid":null,"openalex_id":"https://openalex.org/W2138580185","authors":[],"funders":[],"total_grants":0,"fwci":4.2183,"citation_percentile":0.94999294,"influential_citations":3,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":6},{"year":2014,"count":2},{"year":2015,"count":5},{"year":2016,"count":3},{"year":2017,"count":3},{"year":2018,"count":3},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2021,"count":2},{"year":2023,"count":2}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2559.2004.01766.x","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2559.2004.01766.x","host_type":"publisher"},{"url":"https://doi.org/10.1111/j.1365-2559.2004.01766.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/14764053","host_type":"repository"}],"fields_of_study":["Gene expression and cancer classification","Genomic variations and chromosomal abnormalities","Molecular Biology Techniques and Applications","Biology","Medicine","Animals","Computational Biology","Gene Expression Profiling","Humans","Image Processing, Computer-Assisted","Immunohistochemistry","In Situ Hybridization","Neoplasms","Oligonucleotide Array Sequence Analysis","Pathology, Clinical"],"mesh_terms":["Animals","Humans","Image Processing, Computer-Assisted","Immunohistochemistry","Neoplasms","Pathology, Clinical","In Situ Hybridization","Computational Biology","Oligonucleotide Array Sequence Analysis","Gene Expression Profiling"],"keywords":["Histopathology","DNA microarray","Pathology","Biology","Computational biology","Medicine","Genetics","Gene","Gene expression"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Industry, innovation and infrastructure"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T07:55:58.396809Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}