{"doi":"10.1111/j.1365-2257.2006.00798.x","title":"Quantitation of red cell-bound IgG by an enzyme-linked antiglobulin test in the patients with warm-type autoimmune haemolytic anaemia","abstract":null,"journal":"Clinical &amp; Laboratory Haematology","year":2006,"id":629259,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1629547,"name":"R. POGŁO´D","orcid":null,"position":1,"is_corresponding":false},{"id":1629548,"name":"A. ADAMOWICZ-SALACH","orcid":null,"position":2,"is_corresponding":false},{"id":1629549,"name":"H. ŁOPIEŃSKA","orcid":null,"position":3,"is_corresponding":false},{"id":1629546,"name":"J. FABIJAN´SKA-MITEK","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Quantitation of red cell-bound IgG by an enzyme-linked antiglobulin test in the patients with warm-type autoimmune haemolytic anaemia","abstract":"We have previously reported the evaluation of a gel-direct antiglobulin test and enzyme-linked antiglobulin test (ELAT) in the laboratory diagnosis of autoimmune haemolytic anaemia (AIHA). We now report our experience with quantitative ELAT performed on a large group of patients under long-term observation. The number of IgG molecules/red blood cell was determined in 658 blood samples from 268 randomly selected patients with warm-type AIHA. Eighty-six patients were tested every 2-4 weeks for several months. Laboratory signs of haemolysis were present in 65.7% of blood samples with a small amount of red cell-bound autoantibody (< 200 IgG molecules/red blood cell) and in 70.4% of blood samples with moderately coated red blood cells (200-1000 molecules/red blood cell). Haemolysis was demonstrated in 87.9% samples with > 1000 IgG molecules/red blood cell, which were predominantly IgG3 and C3 complement, the qualitative factors that may increase haemolysis. In 79% of periodically tested patients, the number of IgG autoantibody molecules/red blood cell decreased and this correlated with the improvement of haemolysis parameters. The number of IgG molecules varied in 21% of AIHAs and was associated with poor prognosis.","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16898962","pmcid":null,"openalex_id":"https://openalex.org/W1907744030","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.04122844,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2014,"count":2},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2023,"count":2},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2257.2006.00798.x","host_type":"publisher"},{"url":"http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1365-2257.2006.00798.x/fullpdf","host_type":"publisher"},{"url":"https://doi.org/10.1111/j.1365-2257.2006.00798.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16898962","host_type":"repository"}],"fields_of_study":["Blood groups and transfusion","Erythrocyte Function and Pathophysiology","Blood disorders and treatments","Anemia, Hemolytic, Autoimmune","Coombs Test","Enzyme-Linked Immunosorbent Assay","Erythrocytes","Humans","Immunoglobulin G"],"mesh_terms":["Anemia, Hemolytic, Autoimmune","Coombs Test","Enzyme-Linked Immunosorbent Assay","Erythrocytes","Humans","Immunoglobulin G"],"keywords":["Haemolysis","Autoantibody","Red blood cell","Immunology","Red Cell","Coombs test","Medicine","Hemolysis","Antibody","Blood cell","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"No poverty"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T17:49:28.987160Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}