{"doi":"10.1111/j.1365-2125.1982.tb01961.x","title":"Ranitidine: single dose pharmacokinetics and absolute bioavailability in man.","abstract":"<jats:p>1 Ranitidine single dose pharmacokinetics and absolute bioavailability have been studied in five healthy male volunteers. Following an overnight fast, 150 mg was given intravenously as a bolus injection or orally as a tablet formulation to each subject on separate occasions. 2 Following intravenous administration, plasma levels declined biexponentially. The mean (+/‐ s.d.) distribution half‐life (t 1/2 alpha) was 6.6 +/‐ 1.6 min; plasma half‐life (t 1/2 beta) was 1.7 +/‐ 0.2 h; the volume of distribution (V) was 96 +/‐ 9 1; total body clearance (CL) was 647 +/‐ 94 ml/min and renal clearance (CLR) 520 +/‐ 123 ml/min. 3 Following oral administration plasma levels showed a bimodal pattern with a first peak at 1.1 +/‐ 0.4 h and a second peak at 3 +/‐ 0 h. The absolute availability was 60 +/‐ 17%. The plasma half‐ life (t 1/2) of 2.3 +/‐ 0.4 h was significantly longer (P less than 0.05) after oral than after i.v. administration. 4 Renal excretion of unchanged ranitidine accounted for 79 +/‐ 9% of the dose after i.v. administration and for 27 +/‐ 7% after oral administration. 5 Our results suggest a more extensive biotransformation of ranitidine and biliary excretion of metabolites after oral administration while i.v. administration ranitidine is preferentially excreted unchanged in the urine.</jats:p>","journal":"British Journal of Clinical Pharmacology","year":1982,"id":31008,"datarank":10.362403912116964,"base_score":4.51085950651685,"endowment":4.51085950651685,"self_citation_contribution":0.6766289259775276,"citation_network_contribution":9.685774986139437,"self_endowment_contribution":0.6766289259775276,"citer_contribution":9.685774986139437,"corpus_percentile":null,"corpus_rank":null,"citation_count":90,"citer_count":90,"citers_with_citation_signal":89,"citers_with_endowment":89,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":167154,"name":"TB Tjandramaga","orcid":null,"position":1,"is_corresponding":false},{"id":167155,"name":"A Mullie","orcid":null,"position":2,"is_corresponding":false},{"id":167156,"name":"R Verbesselt","orcid":null,"position":3,"is_corresponding":false},{"id":167157,"name":"PJ De Schepper","orcid":null,"position":4,"is_corresponding":false},{"id":167153,"name":"AM van Hecken","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.51085950651685,"endowment":4.51085950651685,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6125204","pmcid":"PMC1427746","openalex_id":"https://openalex.org/W2093780690","authors":[],"funders":[],"total_grants":0,"fwci":4.2451,"citation_percentile":0.95121951,"influential_citations":3,"citation_trend":[{"year":2012,"count":2},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":4},{"year":2020,"count":1},{"year":2023,"count":4}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1982.tb01961.x","host_type":"journal"},{"url":"https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1982.tb01961.x","host_type":"BRONZE"},{"url":"https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.1982.tb01961.x","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2125.1982.tb01961.x","host_type":"publisher"},{"url":"https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2125.1982.tb01961.x","host_type":"publisher"},{"url":"https://doi.org/10.1111/j.1365-2125.1982.tb01961.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6125204","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1427746","host_type":"repository"}],"fields_of_study":["Drug Transport and Resistance Mechanisms","Antibiotics Pharmacokinetics and Efficacy","Pharmacogenetics and Drug Metabolism","Chemistry","Medicine","Administration, Oral","Adult","Biological Availability","Blood Proteins","Furans","Histamine H2 Antagonists","Humans","Injections, Intravenous","Kinetics","Male","Protein Binding","Ranitidine"],"mesh_terms":["Administration, Oral","Adult","Biological Availability","Blood Proteins","Furans","Histamine H2 Antagonists","Humans","Injections, Intravenous","Kinetics","Male","Protein Binding","Ranitidine"],"keywords":["Pharmacokinetics","Bioavailability","Volume of distribution","Oral administration","Ranitidine","Half-life","Pharmacology","Urine","Bolus (digestion)","Excretion","Medicine","Distribution (mathematics)","Renal physiology","Chemistry","Internal medicine","Renal function","Endocrinology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T06:16:53.927524Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}