{"doi":"10.1111/j.1365-2044.1988.tb06641.x","title":"Propofol: clinical strategies for preventing the pain of injection","abstract":"<jats:title>Summary</jats:title>\n                  <jats:p>Eight modes of administration of propofol were assessed in order to minimise the pain of injection. An intravenous bolus injection in the antecubital fossa was the only approach that caused no pain. When administered intravenously in the dorsum of the hand the pain score and the number of patients who experienced pain was reduced significantly by mixing the agent with lignocaine when compared with a bolus injection. Slowing the speed of injection caused the greatest discomfort. An indirect biochemical mechanism for the pain is proposed.</jats:p>","journal":"Anaesthesia","year":1988,"id":41334,"datarank":30.058228580293388,"base_score":5.968707559985366,"endowment":5.968707559985366,"self_citation_contribution":0.895306133997805,"citation_network_contribution":29.162922446295582,"self_endowment_contribution":0.895306133997805,"citer_contribution":29.162922446295582,"corpus_percentile":null,"corpus_rank":null,"citation_count":390,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":199244,"name":"D.A. Saunders","orcid":null,"position":1,"is_corresponding":false},{"id":199245,"name":"J. Norman","orcid":null,"position":2,"is_corresponding":false},{"id":199243,"name":"R.P.F. Scott","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.968707559985366,"endowment":5.968707559985366,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"3261547","pmcid":null,"openalex_id":"https://openalex.org/W2035230043","authors":[],"funders":[],"total_grants":0,"fwci":4.0451,"citation_percentile":0.93974264,"influential_citations":14,"citation_trend":[{"year":2012,"count":19},{"year":2013,"count":13},{"year":2014,"count":13},{"year":2015,"count":17},{"year":2016,"count":14},{"year":2017,"count":8},{"year":2018,"count":9},{"year":2019,"count":14},{"year":2020,"count":10},{"year":2021,"count":7},{"year":2022,"count":8},{"year":2023,"count":5},{"year":2024,"count":2},{"year":2025,"count":6},{"year":2026,"count":2}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.1988.tb06641.x","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.1988.tb06641.x","host_type":"BRONZE"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2044.1988.tb06641.x","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2044.1988.tb06641.x","host_type":"publisher"},{"url":"https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2044.1988.tb06641.x","host_type":"publisher"},{"url":"https://doi.org/10.1111/j.1365-2044.1988.tb06641.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/3261547","host_type":"repository"}],"fields_of_study":["Anesthesia and Pain Management","Anesthesia and Sedative Agents","Dental Anxiety and Anesthesia Techniques","Medicine","Adolescent","Adult","Aged","Anesthetics","Humans","Injections, Intravenous","Lidocaine","Middle Aged","Pain","Phenols","Propofol","Random Allocation"],"mesh_terms":["Adolescent","Adult","Aged","Anesthetics","Humans","Injections, Intravenous","Lidocaine","Middle Aged","Pain","Phenols","Random Allocation","Propofol"],"keywords":["Medicine","Propofol","Anesthesia","Bolus (digestion)","Intravenous bolus","Surgery"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-12T23:38:55.631737Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}