{"doi":"10.1111/j.0303-6987.2005.320ba.x","title":"Primary Cutaneous Lymphoblastic Lymphoma in Children– Comparison with its Mediastinal Component and Myeloid Sarcoma","abstract":"<jats:p>Lymphoblastic lymphoma (LL) is the second most common subtype of non‐Hodgkin’s lymphoma in children. The majority of LL are derived from immature T cells and present with a mediastinal mass with or without bone marrow involvement. The incidence of subsequent leukemic conversion is high. LL presenting as an isolated tumor in the skin has rarely been described in children. In this study, we reviewed the literature and present four additional cases of childhood primary cutaneous lymphoblastic lymphoma (PCLL). We also contrasted PCLL with mediastinal LL and compared the clinical and prognostic features of PCLL with granulocytic sarcoma (GS). Most tumors occurred in the scalp. Histologically, all cases demonstrated a dense monomorphic dermal infiltrate of intermediate sized cells with scant cytoplasm and inconspicuous nucleoli. The majority of cases were of precursor B phenotype, in contrast to primary mediastinal LL. A number of patients demonstrated concomitant bone marrow involvement at presentation and concurrent or subsequent conversion to acute lympoblastic lymphoma. We believe there are many similarities between PCLL and GS, both in terms of clinical presentation and the association of acute leukemia. Recognition of this uncommon tumor is important so that appropriate clinical workup and therapy may be instituted.</jats:p>","journal":"Journal of Cutaneous Pathology","year":2005,"id":654564,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1708327,"name":"AF Hood","orcid":null,"position":1,"is_corresponding":false},{"id":1708326,"name":"J Cotton","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Primary Cutaneous Lymphoblastic Lymphoma in Children– Comparison with its Mediastinal Component and Myeloid Sarcoma","abstract":"<jats:p>Lymphoblastic lymphoma (LL) is the second most common subtype of non‐Hodgkin’s lymphoma in children. The majority of LL are derived from immature T cells and present with a mediastinal mass with or without bone marrow involvement. The incidence of subsequent leukemic conversion is high. LL presenting as an isolated tumor in the skin has rarely been described in children. In this study, we reviewed the literature and present four additional cases of childhood primary cutaneous lymphoblastic lymphoma (PCLL). We also contrasted PCLL with mediastinal LL and compared the clinical and prognostic features of PCLL with granulocytic sarcoma (GS). Most tumors occurred in the scalp. Histologically, all cases demonstrated a dense monomorphic dermal infiltrate of intermediate sized cells with scant cytoplasm and inconspicuous nucleoli. The majority of cases were of precursor B phenotype, in contrast to primary mediastinal LL. A number of patients demonstrated concomitant bone marrow involvement at presentation and concurrent or subsequent conversion to acute lympoblastic lymphoma. We believe there are many similarities between PCLL and GS, both in terms of clinical presentation and the association of acute leukemia. Recognition of this uncommon tumor is important so that appropriate clinical workup and therapy may be instituted.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19965766","pmcid":null,"openalex_id":"https://openalex.org/W1989051744","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.11375576,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://hdl.handle.net/2027.42/72113","host_type":"repository"},{"url":"https://hdl.handle.net/2027.42/72113","host_type":"repository"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.0303-6987.2005.320ba.x","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.0303-6987.2005.320ba.x","host_type":"publisher"},{"url":"https://doi.org/10.1111/j.0303-6987.2005.320ba.x","host_type":"journal"}],"fields_of_study":["Cutaneous lymphoproliferative disorders research","Lymphoma Diagnosis and Treatment","CNS Lymphoma Diagnosis and Treatment"],"mesh_terms":[],"keywords":["Lymphoblastic lymphoma","Medicine","Pathology","Lymphoma","Myeloid sarcoma","Bone marrow","Sarcoma","CD30","Immunology","T cell"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T07:16:12.527878Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}