{"doi":"10.1111/irv.12832","title":"Symptoms and recovery among adult outpatients with and without COVID‐19 at 11 healthcare facilities—July 2020, United States","abstract":"BACKGROUND: Symptoms of mild COVID-19 illness are non-specific and may persist for prolonged periods. Effects on quality of life of persistent poor physical or mental health associated with COVID-19 are not well understood. METHODS: Adults aged ≥18 years with laboratory-confirmed COVID-19 and matched control patients who tested negative for SARS-CoV-2 infection at outpatient facilities associated with 11 medical centers in the United States were interviewed to assess symptoms, illness duration, and health-related quality of life. Duration of symptoms, health-related quality of life measures, and days of poor physical health by symptoms experienced during illness were compared between case patients and controls using Wilcoxon rank-sum tests. Symptoms associated with COVID-19 case status were evaluated by multivariable logistic regression. RESULTS: Among 320 participants included, 157 were COVID-19 cases and 163 were SARS-CoV-2 negative controls. Loss of taste or smell was reported by 63% of cases and 6% of controls and was strongly associated with COVID-19 in logistic regression models (adjusted odds ratio [aOR] = 32.4; 95% confidence interval [CI], 12.6-83.1). COVID-19 cases were more likely than controls to have experienced fever, body aches, weakness, or fatigue during illness, and to report ≥1 persistent symptom more than 14 days after symptom onset (50% vs 32%, P < .001). Cases reported significantly more days of poor physical health during the past 14 days than controls (P < .01). CONCLUSIONS: Differentiating COVID-19 from other acute illnesses will require widespread diagnostic testing, especially during influenza seasons. Persistent COVID-19-related symptoms may negatively affect quality of life, even among those initially presenting with mild illness.","journal":"Influenza and Other Respiratory Viruses","year":2021,"id":171353,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7124,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":242322,"name":"Samantha M. 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Prekker","orcid":"0000-0002-3969-3022","position":10,"is_corresponding":false},{"id":105986,"name":"Jay S. Steingrub","orcid":"0000-0002-6019-6725","position":11,"is_corresponding":false},{"id":105990,"name":"Matthew C. Exline","orcid":"0000-0001-6797-158X","position":12,"is_corresponding":false},{"id":105991,"name":"Daniel J. Henning","orcid":null,"position":13,"is_corresponding":false},{"id":237081,"name":"Jennifer G. Wilson","orcid":"0000-0002-4254-8475","position":14,"is_corresponding":false},{"id":105995,"name":"Samuel M. Brown","orcid":"0000-0003-1206-6261","position":15,"is_corresponding":false},{"id":105996,"name":"Ithan D. Peltan","orcid":"0000-0003-1730-234X","position":16,"is_corresponding":false},{"id":105997,"name":"Todd W. Rice","orcid":"0000-0002-7136-5408","position":17,"is_corresponding":false},{"id":105998,"name":"David N. Hager","orcid":"0000-0002-5148-4872","position":18,"is_corresponding":false},{"id":105999,"name":"Adit A. Ginde","orcid":"0000-0003-2325-206X","position":19,"is_corresponding":false},{"id":105916,"name":"H. Keipp Talbot","orcid":"0000-0003-0141-1760","position":20,"is_corresponding":false},{"id":242316,"name":"Jonathan D. Casey","orcid":"0000-0002-0977-290X","position":21,"is_corresponding":false},{"id":105907,"name":"Carlos G. Grijalva","orcid":"0000-0002-2329-7797","position":22,"is_corresponding":false},{"id":242317,"name":"Brendan Flannery","orcid":"0000-0001-5041-308X","position":23,"is_corresponding":false},{"id":242318,"name":"Manish M. Patel","orcid":"0000-0001-8949-6548","position":24,"is_corresponding":false},{"id":106003,"name":"Leora R. Feldstein","orcid":"0000-0002-4430-6760","position":25,"is_corresponding":false},{"id":242314,"name":"Kiva A. Fisher","orcid":"0000-0002-5045-7944","position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":null,"created_at":"2026-07-18T23:46:28.747384Z","pmid":"33405338","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}