{"doi":"10.1111/imcb.70125","title":"From transcription to biological translation: regulation and recognition of\n                    <scp>MR1</scp>","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    The axis of MR1 restricted T‐cell immunity has been an area of growing interest over the past decade. In this “Highlights of 2025” perspective, we discuss recent advances in our understanding of the transcriptional regulation of\n                    <jats:italic>MR1</jats:italic>\n                    , the distribution of MR1 protein across tissues and the elucidation of novel MR1 ligands. The advances of 2025 have unlocked new methodologies and mechanistic insights, aiding future studies that consider MR1 and its contribution to the development of MR1‐restricted T‐cell responses in the context of infection, cancer and autoimmunity.\n                  </jats:p>","journal":"Immunology &amp; Cell Biology","year":2026,"id":642139,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":654814,"name":"Adam G. Nelson","orcid":"0000-0002-5897-791X","position":1,"is_corresponding":false},{"id":256184,"name":"Alexandra J. Corbett","orcid":"0000-0003-1618-4337","position":2,"is_corresponding":false},{"id":524030,"name":"Timothy Patton","orcid":"0000-0002-9642-7003","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"From transcription to biological translation: regulation and recognition of\n                    <scp>MR1</scp>","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    The axis of MR1 restricted T‐cell immunity has been an area of growing interest over the past decade. In this “Highlights of 2025” perspective, we discuss recent advances in our understanding of the transcriptional regulation of\n                    <jats:italic>MR1</jats:italic>\n                    , the distribution of MR1 protein across tissues and the elucidation of novel MR1 ligands. The advances of 2025 have unlocked new methodologies and mechanistic insights, aiding future studies that consider MR1 and its contribution to the development of MR1‐restricted T‐cell responses in the context of infection, cancer and autoimmunity.\n                  </jats:p>","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"42023437","pmcid":null,"openalex_id":"https://openalex.org/W7155371059","authors":[],"funders":[],"total_grants":0,"fwci":4.1193,"citation_percentile":0.93863376,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"closed","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/imcb.70125","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/imcb.70125","host_type":"publisher"},{"url":"https://doi.org/10.1111/imcb.70125","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/42023437","host_type":"repository"}],"fields_of_study":["Immune Cell Function and Interaction","T-cell and B-cell Immunology","Immunotherapy and Immune Responses","Humans","Animals","Transcription, Genetic","Protein Biosynthesis","Histocompatibility Antigens Class I","Minor Histocompatibility Antigens","Gene Expression Regulation","Ligands","T-Lymphocytes"],"mesh_terms":["Animals","Gene Expression Regulation","Humans","Ligands","T-Lymphocytes","Transcription, Genetic","Protein Biosynthesis","Histocompatibility Antigens Class I","Minor Histocompatibility Antigens"],"keywords":["Transcription (linguistics)","Context (archaeology)","Transcription factor","Transcriptional activity","Transcriptional regulation","Immunity","Mr1","Mait cell","Mr1t cell","Mr1‐ligand"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T21:41:32.412871Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}