{"doi":"10.1111/imcb.12566","title":"SATB1 ensures appropriate transcriptional programs within naïve CD8<sup>+</sup> T cells","abstract":"Abstract Special AT‐binding protein 1 (SATB1) is a chromatin‐binding protein that has been shown to be a key regulator of T‐cell development and CD4 + T‐cell fate decisions and function. The underlying function for SATB1 in peripheral CD8 + T‐cell differentiation processes is largely unknown. To address this, we examined SATB1‐binding patterns in naïve and effector CD8 + T cells demonstrating that SATB1 binds to noncoding regulatory elements linked to T‐cell lineage–specific gene programs, particularly in naïve CD8 + T cells. We then assessed SATB1 function using N ‐ethyl‐ N ‐nitrosourea‐mutant mice that exhibit a point mutation in the SATB1 DNA‐binding domain (termed Satb1 m1Anu/m1Anu ). Satb1 m1Anu/m1Anu mice exhibit diminished SATB1‐binding, naïve, Satb1 m1Anu/m1Anu CD8 + T cells exhibiting transcriptional and phenotypic characteristics reminiscent of effector T cells. Upon activation, the transcriptional signatures of Satb1 m1Anu/m1Anu and wild‐type effector CD8 + T cells converged. While there were no overt differences, primary respiratory infection of Satb1 m1Anu/m1Anu mice with influenza A virus (IAV) resulted in a decreased proportion and number of IAV‐specific CD8 + effector T cells recruited to the infected lung when compared with wild‐type mice. Together, these data suggest that SATB1 has a major role in an appropriate transcriptional state within naïve CD8 + T cells and ensures appropriate CD8 + T‐cell effector gene expression upon activation.","journal":"Immunology and Cell Biology","year":2022,"id":265877,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":656802,"name":"Lisa A. Miosge","orcid":"0000-0001-8317-3377","position":1,"is_corresponding":false},{"id":925470,"name":"Kah Lee","orcid":null,"position":2,"is_corresponding":false},{"id":580328,"name":"Moshe Olshansky","orcid":"0000-0003-2085-9851","position":3,"is_corresponding":false},{"id":764699,"name":"Adele Barugahare","orcid":"0000-0002-8976-0094","position":4,"is_corresponding":false},{"id":814008,"name":"Carla M. Roots","orcid":null,"position":5,"is_corresponding":false},{"id":925025,"name":"Yovina Sontani","orcid":"0000-0001-9553-5304","position":6,"is_corresponding":false},{"id":925471,"name":"E. Bridie Day","orcid":null,"position":7,"is_corresponding":false},{"id":925026,"name":"Marios Koutsakos","orcid":"0000-0001-9994-9723","position":8,"is_corresponding":false},{"id":104934,"name":"Katherine Kedzierska","orcid":"0000-0001-6141-335X","position":9,"is_corresponding":false},{"id":656807,"name":"Christopher C. Goodnow","orcid":"0000-0001-5296-6155","position":10,"is_corresponding":false},{"id":925027,"name":"Brendan E. Russ","orcid":"0000-0001-6862-5283","position":11,"is_corresponding":false},{"id":659741,"name":"Stephen R. Daley","orcid":"0000-0002-5870-644X","position":12,"is_corresponding":false},{"id":925472,"name":"Stephen J Turner","orcid":null,"position":13,"is_corresponding":false},{"id":656799,"name":"Simone Nüssing","orcid":"0000-0002-0685-3413","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T00:26:49.862989Z","pmid":"35713361","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}