{"doi":"10.1111/imcb.12495","title":"Neutralizing type‐I interferon autoantibodies are associated with delayed viral clearance and intensive care unit admission in patients with COVID‐19","abstract":"Type-I interferons (IFNs) mediate antiviral activity and have emerged as important immune mediators during coronavirus disease 19 (COVID-19). Several lines of evidence suggest that impaired type-I IFN signaling may predispose to severe COVID-19. However, the pathophysiologic mechanisms that contribute to illness severity remain unclear. In this study, our goal was to gain insight into how type-I IFNs influence outcomes in patients with COVID-19. To achieve this goal, we compared clinical outcomes between 26 patients with neutralizing type-I IFN autoantibodies (AAbs) and 192 patients without AAbs who were hospitalized for COVID-19 at three Italian hospitals. The presence of circulating AAbs to type-I IFNs was associated with an increased risk of admission to the intensive care unit and a delayed time to viral clearance. However, survival was not adversely affected by the presence of type-I IFN AAbs. Our findings provide further support for the role of type-I IFN AAbs in impairing host antiviral defense and promoting the development of critical COVID-19 pneumonia in severe acute respiratory syndrome coronavirus 2-infected individuals.","journal":"Immunology and Cell Biology","year":2021,"id":149900,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":100,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9615,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":104139,"name":"Lindsey B. Rosen","orcid":"0000-0001-5894-3878","position":1,"is_corresponding":false},{"id":104168,"name":"Ottavia M. Delmonte","orcid":"0000-0002-4772-0799","position":2,"is_corresponding":false},{"id":104149,"name":"Elana Shaw","orcid":"0000-0001-9265-8026","position":3,"is_corresponding":false},{"id":104138,"name":"Paul Bastard","orcid":"0000-0002-5926-8437","position":4,"is_corresponding":false},{"id":104205,"name":"Luisa Imberti","orcid":"0000-0002-2075-8391","position":5,"is_corresponding":false},{"id":637092,"name":"Virginia Quaresima","orcid":"0000-0001-8858-3236","position":6,"is_corresponding":false},{"id":104195,"name":"Andrea Biondi","orcid":"0000-0002-6757-6173","position":7,"is_corresponding":false},{"id":104198,"name":"Paolo Bonfanti","orcid":"0000-0001-7289-8823","position":8,"is_corresponding":false},{"id":104210,"name":"Riccardo Castagnoli","orcid":"0000-0003-0029-9383","position":9,"is_corresponding":false},{"id":57373,"name":"Jean-Laurent Casanova","orcid":"0000-0002-7782-4169","position":10,"is_corresponding":false},{"id":231244,"name":"Helen C. Su","orcid":"0000-0002-5582-9110","position":11,"is_corresponding":false},{"id":231247,"name":"Luigi D. Notarangelo","orcid":"0000-0002-8335-0262","position":12,"is_corresponding":false},{"id":104227,"name":"Steven M. Holland","orcid":"0000-0003-3207-5464","position":13,"is_corresponding":false},{"id":104225,"name":"Michail S. Lionakis","orcid":"0000-0003-4994-9500","position":14,"is_corresponding":false},{"id":104169,"name":"Michael S. Abers","orcid":"0000-0003-2234-2813","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-18T23:42:56.251607Z","pmid":"34309902","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}