{"doi":"10.1111/ijpo.13185","title":"Association between total, regional and organ fat and type 2 diabetes risk factors among Latino youth: A longitudinal study","abstract":"INTRODUCTION: To examine whether within-person changes in total, regional and organ fat were associated with within-person changes in type 2 diabetes (T2D)-related biomarkers following interventions. METHODS: A secondary analysis from a randomised trial among Latino youth (30 males, 25 females) aged 12-16 years with obesity. The study sample combined participants randomised to either lifestyle intervention (N = 39) or usual care (N = 16). Total body composition was assessed by DEXA. Hepatic and pancreatic fat fractions were assessed using MRI. T2D risk factors included insulin sensitivity, beta-cell function and post-challenge glucose. RESULTS: Significant changes in %body fat, lean mass, insulin sensitivity and 2-h glucose were observed. Changes in fat mass were associated with changes in insulin sensitivity (β = -0.45, p < 0.001), while changes in lean mass were associated with changes in 2-h glucose concentrations (β = -0.50, p = 0.02). No association between changes in total, regional, or organ fat and beta cell function were noted. CONCLUSIONS: Our study revealed that within-person changes in fat mass and lean mass were associated with increased insulin sensitivity and reduced 2-h glucose concentrations, respectively, among high-risk Latino youth. The impact of reductions in regional and organ fat deposition on T2D risk factors warrants further examination.","journal":"Pediatric Obesity","year":2024,"id":477975,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7927,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":516468,"name":"Micah L. Olson","orcid":"0000-0002-9182-961X","position":1,"is_corresponding":false},{"id":443145,"name":"Peng Hu","orcid":"0000-0002-0719-1159","position":2,"is_corresponding":false},{"id":516472,"name":"Armando Peña","orcid":"0000-0002-8219-9433","position":3,"is_corresponding":false},{"id":517099,"name":"Janiel Pimentel","orcid":null,"position":4,"is_corresponding":false},{"id":946952,"name":"Keenan A. Pituch","orcid":"0000-0003-0768-6490","position":5,"is_corresponding":false},{"id":792669,"name":"Smita S. Bailey","orcid":null,"position":6,"is_corresponding":false},{"id":334002,"name":"Gabriel Q. Shaibi","orcid":"0000-0002-6890-2903","position":7,"is_corresponding":false},{"id":1316516,"name":"Eyitayo Omolara Owolabi","orcid":"0000-0001-5575-7842","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T02:06:42.155024Z","pmid":"39552174","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}