{"doi":"10.1111/ijpo.13168","title":"Genetic associations with consumption of palatable foods in the absence of hunger in response to food cues in children","abstract":"OBJECTIVE: The objective of this study is to evaluate obesity-related genetic factors in relation to excess consumption and assess if food cues modify associations. METHODS: Children (9-12 years) completed a randomized crossover experiment. During two visits, children ate a preload and then snacks ad libitum while watching television, embedded with food or non-food advertisements to assess eating in the absence of hunger (EAH). Primary exposures were obesity-associated genotypes, FTO rs9939609 and MC4R rs571312, and a paediatric-specific polygenic risk score (PRS). Outcomes included consumption of all snacks (total EAH) and gummy candy only (gummy candy EAH). Linear mixed-effects models tested whether genetic exposures related to EAH outcomes. We tested for effect modification by food cues using multiplicative interaction terms. RESULTS: Among 177 children, each FTO risk allele was associated with a 30% increase in gummy candy EAH (p = 0.025) in adjusted models. Food cue exposure exacerbated associations between the FTO variant with gummy candy EAH (p = 0.046). No statistically significant associations were found between MC4R and EAH. CONCLUSION: The results suggest children with the FTO rs9939609 risk allele may be predisposed to excess consumption of candy and that this association may be exacerbated by food cues.","journal":"Pediatric Obesity","year":2024,"id":468997,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1109099,"name":"Timothy J. Renier","orcid":"0000-0001-8949-0090","position":1,"is_corresponding":false},{"id":318785,"name":"Travis D. Masterson","orcid":"0000-0002-5470-4041","position":2,"is_corresponding":false},{"id":1095159,"name":"Delaina D. Carlson","orcid":"0009-0000-1928-6967","position":3,"is_corresponding":false},{"id":1095589,"name":"Grace A. Ballarino","orcid":null,"position":4,"is_corresponding":false},{"id":1095588,"name":"Reina K. Lansigan","orcid":null,"position":5,"is_corresponding":false},{"id":1082,"name":"Ruth J. F. Loos","orcid":"0000-0002-8532-5087","position":6,"is_corresponding":false},{"id":348315,"name":"Jennifer A. Emond","orcid":"0000-0001-8684-7330","position":7,"is_corresponding":false},{"id":348316,"name":"Diane Gilbert‐Diamond","orcid":"0000-0003-3560-7171","position":8,"is_corresponding":false},{"id":958539,"name":"Dabin Yeum","orcid":"0000-0001-9575-4849","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:05:28.027781Z","pmid":"39197865","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}